Evidence mapPaperPMID 38675408Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

The Lipid-Lowering Efficacy of a Nutraceutical Combination Including Leucoselect Phytosome, Red Yeast Rice, Policosanol and Folic Acid in Dyslipidaemia Patients: Real-World Insights.

Vincenzo Russo, Nicola Napolitano, Antonia Ascrizzi, Silvia Leonardi, Filomena Pisacane, Pierpaolo Di Micco, Egidio Imbalzano, Ferdinando Carlo Sasso, Antonello D'Andrea, Alfredo Caturano and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  6. Advances in the Insulin-Heart Axis: Current Therapies and Future Directions.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Vincenzo RussoCardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.ORCID 0000-0002-9227-0360
Nicola NapolitanoCardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.
Antonia AscrizziCardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.
Silvia LeonardiClinical Biochemistry Unit, Monaldi Hospital, 80131 Naples, Italy.
Filomena PisacaneClinical Biochemistry Unit, Monaldi Hospital, 80131 Naples, Italy.
Pierpaolo Di MiccoDepartment of Medicine, Presidio Ospedaliero Santa Maria delle Grazie, 80078 Pozzuoli, Italy.ORCID 0000-0002-8484-4598
Egidio ImbalzanoDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0003-2656-5467
Ferdinando Carlo SassoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-9142-7848
Antonello D'AndreaDepartment of Cardiology, Umberto I Hospital, 84014 Nocera Inferiore, Italy.ORCID 0000-0002-9698-9145
Alfredo CaturanoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-7761-7533
Alfredo MaurielloCardiology Unit, Department of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, 80131 Naples, Italy.ORCID 0000-0001-7060-6938
University of Campania "Luigi Vanvitelli" · ITOspedale Monaldi · ITPoliclinico Umberto I · ITPresidio Ospedaliero · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease is a global health concern and reducing plasma LDL-C levels is a major goal in cardiovascular prevention. Our study aimed to evaluate the effectiveness of a nutraceutical formulation including leucoselect MATERIALS AND

methodsWe prospectively enrolled all consecutive patients with dyslipidemia at low cardiovascular risk who were unresponsive to diet and physical activity. Clinical assessments and laboratory analyses, encompassing lipid profile, hepatic function, and CPK levels, were performed at baseline prior to initiating treatment and repeated at the 12-week mark following administration of the study nutraceutical.

resultsSixty (60) consecutive patients (mean age 48.02 ± 10.1 years; 60% male) were included. At the 12-week follow-up, a statistically significant reduction in Total Cholesterol (13.1%) and LDL-c serum level (20.4%) was observed. Hepatic and muscular function remain stable over the time. The adherence to therapy was 99% and the persistence was maximum.

conclusionsThe nutraceutical formulation including leucoselect

Indexed as

adherenceberberinecardiovascular riskcholesterolfolic acidleucoselect phytosomenutraceuticalspolicosanolred yeast ricesafety profile

Identifiers

PMID38675408
PMCPMC11053596
OpenAlexW4393352952

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.