Evidence mapPaperPMID 38675595Full record

ArticleMolecules (Basel, Switzerland)2024

The Development of Aptamer-Based Gold Nanoparticle Lateral Flow Test Strips for the Detection of SARS-CoV-2 S Proteins on the Surface of Cold-Chain Food Packaging.

Xiaotong Li, Jiachen Wang, Ge Yang, Xiaona Fang, Lianhui Zhao, Zhaofeng Luo, Yiyang Dong

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Xiaotong LiLaboratory of Food Safety and Risk Assessment, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Jiachen WangLaboratory of Food Safety and Risk Assessment, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Ge YangCAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xiaona FangDepartment of Basic Medicine, Anhui Medical College, Hefei 230601, China.ORCID 0000-0003-2545-6509
Lianhui ZhaoLaboratory of Food Safety and Risk Assessment, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Zhaofeng LuoKey Laboratory of Zhejiang Province for Aptamers and Theragnostic, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China.
Yiyang DongLaboratory of Food Safety and Risk Assessment, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0003-1752-3935
Beijing University of Chemical Technology · CNAnhui Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CN

Funding

Beijing University of Chemical Technology-China-Japan Friendship Hospital Biomedical Trans-formation Engineering Research Center Joint Project RZ2020-02National Key Research and Development Program of China 2016YFF0203703
6 · The paper itself

Abstract

The COVID-19 pandemic over recent years has shown a great need for the rapid, low-cost, and on-site detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, an aptamer-based colloidal gold nanoparticle lateral flow test strip was well developed to realize the visual detection of wild-type SARS-CoV-2 spike proteins (SPs) and multiple variants. Under the optimal reaction conditions, a low detection limit of SARS-CoV-2 S proteins of 0.68 nM was acquired, and the actual detection recovery was 83.3% to 108.8% for real-world samples. This suggests a potential tool for the prompt detection of SARS-CoV-2 with good sensitivity and accuracy, and a new method for the development of alternative antibody test strips for the detection of other viral targets.

Indexed as

Aptamers, NucleotideCOVID-19GoldMetal NanoparticlesSARS-CoV-2Spike Glycoprotein, CoronavirusHumansLimit of DetectionReagent StripsAptamers, NucleotideGoldReagent StripsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2aptamerAuNPsCOVID-19lateral flow test stripsSARS-CoV-2S protein

Identifiers

PMID38675595
PMCPMC11052266
OpenAlexW4394815906

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.