Evidence map›Paper›PMID 38675722›Full record

ArticleMolecules (Basel, Switzerland)2024

Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus.

Mohamed E Elangeeb, Imadeldin Elfaki, Ali M S Eleragi, Elsadig Mohamed Ahmed, Rashid Mir, Salem M Alzahrani, Ruqaiah I Bedaiwi, Zeyad M Alharbi, Mohammad Muzaffar Mir, Mohammad Rehan Ajmal and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Mohamed E ElangeebDepartment of Basic Medical Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 61922, Saudi Arabia.ORCID 0000-0002-7191-1675
Imadeldin ElfakiDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Ali M S EleragiDepartment of Microbiology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.ORCID 0000-0001-6475-6382
Elsadig Mohamed AhmedDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 61922, Saudi Arabia.
Rashid MirDepartment of Medical Laboratory Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Salem M AlzahraniDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0009-0003-3100-9788
Ruqaiah I BedaiwiDepartment of Medical Laboratory Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0001-8621-8614
Zeyad M AlharbiDepartment of Medical Laboratory Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Mohammad Muzaffar MirDepartment of Clinical Biochemistry, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.ORCID 0000-0003-2068-3075
Mohammad Rehan AjmalDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-2480-9379
Faris Jamal TayebDepartment of Medical Laboratory Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-8906-198X
Jameel BarnawiDepartment of Medical Laboratory Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
University of Tabuk · SAUniversity of Bisha · SAUniversity of El Imam El Mahdi · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease. In addition to the very bad socioeconomic impacts, it influences patients and their families and communities. The global costs of DM and its complications are huge and expected to rise by the year 2030. DM is caused by genetic and environmental risk factors. Genetic testing will aid in early diagnosis and identification of susceptible individuals or populations using ATP-sensitive potassium (K

Indexed as

Diabetes MellitusMolecular Dynamics SimulationPotassium Channels, Inwardly RectifyingBinding SitesGenetic Predisposition to DiseaseHumansKcnj11 ChannelMutationProtein BindingKcnj11 ChannelPotassium Channels, Inwardly RectifyingATP-sensitive potassium channels (KATP channels)bioinformaticsdiabetes mellitusgenetic testingKCNJ11 genensSNPs

Identifiers

PMID38675722
PMCPMC11054064
OpenAlexW4395012381

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.