Evidence map›Paper›PMID 38675757›Full record

ArticleVaccines2024

Mucosal Immunization with Spore-Based Vaccines against

Muhammed Salah Uddin, Angelo Kaldis, Rima Menassa, José Ortiz Guluarte, Daniel R Barreda, Le Luo Guan, Trevor W Alexander

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. IFI204 RestrictsMicroorganisms · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Muhammed Salah UddinLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, Canada.ORCID 0000-0002-3582-2915
Angelo KaldisLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
Rima MenassaLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
José Ortiz GuluarteLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, Canada.
Daniel R BarredaDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Le Luo GuanDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Trevor W AlexanderLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, Canada.
Agriculture and Agri-Food Canada · CAUniversity of Alberta · CAUniversity of British Columbia · CA

Funding

Alberta Beef Producers 2023F281RResults Driven Agriculture Research Project #2023F281R
6 · The paper itself

Abstract

background

methodsTwo antigen constructs composed of cholera toxin B subunit,

resultsIn both mice experiments, intramuscular immunization induced the strongest serum IgG antibody response. However, the intranasal administration of Spore-MhCP1 and Spore-MhCP2 elicited the greatest secretory IgA-specific response against leukotoxin, PlpE, and GS60 in bronchoalveolar lavage, saliva, and feces (

conclusionsSince intranasally delivered Spore-MhCP1 and Spore-MhCP2 elicited both systemic and mucosal immune responses in mice, these vaccines may have potential to mitigate lung infection in cattle by restricting

Indexed as

Bacillus subtilis sporebovine respiratory diseaseMannheimia haemolyticamucosal vaccinespore-based vaccine

Identifiers

PMID38675757
PMCPMC11054499
OpenAlexW4393378386

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.