Evidence mapPaperPMID 38675839Full record

ArticleViruses2024

Human and Viral microRNA Expression in Acute and Chronic HIV Infections.

Elisabetta Lazzari, Gabriella Rozera, Roberta Gagliardini, Rozenn Esvan, Annalisa Mondi, Valentina Mazzotta, Marta Camici, Enrico Girardi, Andrea Antinori, Fabrizio Maggi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elisabetta LazzariLaboratory of Virology, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0009-0008-0558-0610
Gabriella RozeraLaboratory of Virology, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
Roberta GagliardiniClinical Department, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0002-6351-2623
Rozenn EsvanAIDS Referral Center, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-6127-0045
Annalisa MondiClinical Department, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
Valentina MazzottaClinical Department, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0002-0240-7504
Marta CamiciClinical Department, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0002-6624-7917
Enrico GirardiScientific Direction, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-8182-5896
Andrea AntinoriClinical Department, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0003-2121-4684
Fabrizio MaggiLaboratory of Virology, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Isabella AbbateLaboratory of Virology, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · IT

Funding

Italian Ministry of Health (Ricerca Corrente Linea 2, INMI L. Spallanzani, IRCCS)
6 · The paper itself

Abstract

Human and viral microRNAs (miRNAs) are involved in the regulation of gene transcription, and the establishment of their profiles in acute (AHI) and chronic (CHI) HIV infections may shed light on the pathogenetic events related to different phases of HIV disease. Next-generation sequencing (NGS) of miRNA libraries was performed, and the reads were used to analyze miRNA differential expression in the plasma with AHI and CHI. Functional analysis was then undertaken to investigate the biological processes characterizing the two phases of HIV infection. Except for hsa-miR-122-5p, which was found in 3.39% AHI vs. 0.18% CHI, the most represented human miRNAs were similarly represented in AHI and CHI. However, when considering the overall detected miRNAs in AHI and CHI, 15 displayed differential expression (FDR

Indexed as

High-Throughput Nucleotide SequencingHIV InfectionsMicroRNAsRNA, ViralAcute DiseaseAdultChronic DiseaseFemaleGene Expression ProfilingGene Expression RegulationHIV-1HumansImmunity, InnateMaleMiddle AgedMicroRNAsRNA, Viralacute HIV infectionmiRNA expressionpathogenesistranscription

Identifiers

PMID38675839
PMCPMC11054094
OpenAlexW4393158193

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.