Evidence map›Paper›PMID 38676447›Full record

ArticleEndocrine reviews2024

Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.

Andrea Giustina, John P Bilezikian, Robert A Adler, Giuseppe Banfi, Daniel D Bikle, Neil C Binkley, Jens Bollerslev, Roger Bouillon, Maria Luisa Brandi, Felipe F Casanueva and 17 more

Registry-linked trialOpen access · hybridAbstract readConsensus Statement
In one paragraph

Article in Endocrine reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07479303 (Evaluation of Vitamin D Status in Young Medical Residents at the Reina Sofia University Hospital in Cordoba), which is not on this map. Cited by 223 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed, 12 pooled it
105.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07479303 completednot on this mapstarted 2025, after this paper: background citation

Evaluation of Vitamin D Status in Young Medical Residents at the Reina Sofia University Hospital in Cordoba

Typeobservational_patient_registrySponsorMaimónides Biomedical Research Institute of CórdobaRan2025 to 2025Enrolled30ConditionsVitamin D DeficiencyArmsCalcifediol (Vitamin D)
3 · Its place in the literature

Who cites it

223 citing papers in PubMed, 12 syntheses or guidelines pooled it, 248 citations in OpenAlex.

  1. Pooled it
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  12. The Lebanese GRADE-based vitamin D guidelines: a paradigm for the MENA region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Guideline
  13. Trial
  14. Trial
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  20. Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review

163 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 19 institutions in 11 countries.

Andrea GiustinaInstitute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS Hospital, Milan 20132, Italy.ORCID 0000-0001-6783-3398
John P BilezikianDepartment of Medicine, Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0002-1570-2617
Robert A AdlerRichmond Veterans Affairs Medical Center and Virginia Commonwealth University, Richmond, VA 23284, USA.
Giuseppe BanfiIRCCS Galeazzi Sant'Ambrogio Hospital, Milano 20161, Italy.ORCID 0000-0001-9578-5338
Daniel D BikleDepartment of Medicine, University of California and San Francisco Veterans Affairs Health Center, San Francisco, CA 94121-1545, USA.ORCID 0000-0002-1040-475X
Neil C BinkleySchool of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0002-9905-461X
Jens BollerslevFaculty of Medicine, University of Oslo, Oslo 0313, Norway.ORCID 0000-0002-0654-4610
Roger BouillonLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-6446-3763
Maria Luisa BrandiItalian Foundation for the Research on Bone Diseases (F.I.R.M.O.), Florence 50129, Italy.ORCID 0000-0001-9309-6248
Felipe F CasanuevaDepartment of Medicine, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario and CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Santiago de Compostela University, Santiago de Compostela 15706, Spain.
Luigi di FilippoInstitute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS Hospital, Milan 20132, Italy.
Lorenzo M DoniniDepartment of Experimental Medicine, Sapienza University, Rome 00161, Italy.
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton 3168, Australia.
Ghada El-Hajj FuleihanCalcium Metabolism and Osteoporosis Program, WHO CC for Metabolic Bone Disorders, Division of Endocrinology, American University of Beirut, Beirut 1107 2020, Lebanon.
Angelo FassioRheumatology Unit, University of Verona, Verona 37129, Italy.
Stefano FraraInstitute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS Hospital, Milan 20132, Italy.ORCID 0000-0002-1308-5598
Glenville JonesDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, ON K7L 3N6, Canada.
Claudio MarcocciDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy.
Adrian R MartineauFaculty of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Salvatore MinisolaDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome 00161, Italy.ORCID 0000-0001-6525-0439
Nicola NapoliUnit of Endocrinology and Diabetes Campus Bio-Medico, University of Rome, Rome 00128, Italy.ORCID 0000-0002-3091-8205
Massimo ProcopioDivision of Endocrinology, Diabetology and Metabolic Diseases, "Molinette" Hospital, University of Turin, Turin 10126, Italy.
René RizzoliGeneva University Hospitals and Faculty of Medicine, Geneva 1205, Switzerland.
Anne L SchaferDepartment of Medicine, University of California and San Francisco Veterans Affairs Health Center, San Francisco, CA 94121-1545, USA.
Christopher T SemposVitamin D Standardization Program (VDSP), Havre de Grace, MD 21078, USA.
Fabio Massimo UlivieriInstitute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS Hospital, Milan 20132, Italy.
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio FI-70211, Finland.ORCID 0000-0002-0648-999X
Vita-Salute San Raffaele University · ITSan Francisco VA Medical Center · USSapienza University of Rome · ITAmerican University of Beirut · LBCentro de Investigación Biomédica en Red · ESFondazione Ricerca Molinette · ITGrace (United States) · USKU Leuven · BEMonash University · AUQueen Mary University of London · GBQueen's University · CAUniversità Campus Bio-Medico · ITUniversity Hospital of Geneva · CHUniversity of Eastern Finland · FIUniversity of Oslo · NOUniversity of Pisa · ITUniversity of Verona · ITUniversity of Wisconsin–Madison · USVirginia Commonwealth University · US

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
Abiogen PharmaNIAMS NIH HHS P30 AR075055
6 · The paper itself

Abstract

The 6th International Conference, "Controversies in Vitamin D," was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake and that can be detected with distinctive noncanonical vitamin D metabolites. Optimal 25-hydroxyvitamin D (25(OH)D) levels remain debated. Varying recommendations from different societies arise from evaluating different clinical or public health approaches. The lack of assay standardization also poses challenges in interpreting data from available studies, hindering rational data pooling and meta-analyses. Beyond the well-known skeletal features, interest in vitamin D's extraskeletal effects has led to clinical trials on cancer, cardiovascular risk, respiratory effects, autoimmune diseases, diabetes, and mortality. The initial negative results are likely due to enrollment of vitamin D-replete individuals. Subsequent post hoc analyses have suggested, nevertheless, potential benefits in reducing cancer incidence, autoimmune diseases, cardiovascular events, and diabetes. Oral administration of vitamin D is the preferred route. Parenteral administration is reserved for specific clinical situations. Cholecalciferol is favored due to safety and minimal monitoring requirements. Calcifediol may be used in certain conditions, while calcitriol should be limited to specific disorders in which the active metabolite is not readily produced in vivo. Further studies are needed to investigate vitamin D effects in relation to the different recommended 25(OH)D levels and the efficacy of the different supplementary formulations in achieving biochemical and clinical outcomes within the multifaced skeletal and extraskeletal potential effects of vitamin D.

Indexed as

Dietary SupplementsVitamin DVitamin D DeficiencyHumansReview Literature as Topic25-hydroxyvitamin DVitamin Dcalcifediolcalcitriolcholecalciferolvitamin Dvitamin D assayVitamin D Standardization Program (VDSP)

Identifiers

PMID38676447
PMCPMC11405507
OpenAlexW4395699495

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.