Evidence map›Paper›PMID 38680913›Full record

ArticleFrontiers in microbiology2024

Recombinant probiotic

Juliana Guimarães Laguna, Andria Dos Santos Freitas, Fernanda Alvarenga Lima Barroso, Luís Cláudio Lima De Jesus, Octávio Augusto Greco Gomes De Vasconcelos, Ludmila Silva Quaresma, Monique Ferrary Américo, Gabriela Munis Campos, Rafael de Assis Glória, Joyce da Cruz Ferraz Dutra and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Recombinant Molecules as a New Frontier in Mucositis Therapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  4. Article
  5. Review
  6. Microbiota composition and intestinal barrier function modulated by tamsulosin andFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Juliana Guimarães LagunaDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Andria Dos Santos FreitasDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Fernanda Alvarenga Lima BarrosoDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Luís Cláudio Lima De JesusDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Octávio Augusto Greco Gomes De VasconcelosDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Ludmila Silva QuaresmaDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Monique Ferrary AméricoDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Gabriela Munis CamposDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Rafael de Assis GlóriaDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Joyce da Cruz Ferraz DutraDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Tales Fernando Da SilvaDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Kátia Duarte VitalDepartment of Clinical Analysis and Toxicology, Federal University of Minas Gerais Belo Horizonte, Minas Gerais, Brazil.
Simone O FernandesDepartment of Clinical Analysis and Toxicology, Federal University of Minas Gerais Belo Horizonte, Minas Gerais, Brazil.
Ramon O SouzaDepartment of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Flaviano Dos Santos MartinsDepartment of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Enio FerreiraDepartment of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Túlio Marcos SantosDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Alexander BirbrairDepartment of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Marcos Felipe Andrade De OliveiraDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Ana Maria Caetano FariaDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Rodrigo Dias de Oliveira CarvalhoDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Franco Maria VenanziSchool of Biosciences and Veterinary Medicine, University of Camerino, Matelica, Italy.
Yves Le LoirSTLO, INRAE, Institut Agro, Rennes, Brazil.
Gwénaël JanSTLO, INRAE, Institut Agro, Rennes, Brazil.
Éric GuédonSTLO, INRAE, Institut Agro, Rennes, Brazil.
Vasco Ariston de Carvalho AzevedoDepartment of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction and objective: p62 is a human multifunctional adaptor protein involved in key cellular processes such as tissue homeostasis, inflammation, and cancer. It acts as a negative regulator of inflammasome complexes. It may thus be considered a good candidate for therapeutic use in inflammatory bowel diseases (IBD), such as colitis. Probiotics, including recombinant probiotic strains producing or delivering therapeutic biomolecules to the host mucosal surfaces, could help prevent and mitigate chronic intestinal inflammation. The objective of the present study was to combine the intrinsic immunomodulatory properties of the probiotic Material and methods: This study was realized Results and discussion: No protective effect of

Indexed as

epithelial barriergut microbiotaimmunomodulationinflammatory bowel diseaseprobiotic bacteriarecombinant protein

Identifiers

PMID38680913
PMCPMC11047439

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.