Evidence map›Paper›PMID 38683449›Full record

ArticlePain and therapy2024

A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia.

Ilenia Casini, Valeria Ladisa, Livio Clemente, Marianna Delussi, Elvira Rostanzo, Sofia Peparini, Anna Maria Aloisi, Marina de Tommaso

Registry-linked trialAbstract read
In one paragraph

Article in Pain and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07403929 (Determination of the Effect of Fermented Grape Juice Consumption on Oxidative Stress and Inflammation Biomarkers and SIRT-1 Levels in Fibromyalgia Patients), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07403929 narecruitingnot on this mapstarted 2026, after this paper: background citation

Determination of the Effect of Fermented Grape Juice Consumption on Oxidative Stress and Inflammation Biomarkers and SIRT-1 Levels in Fibromyalgia Patients

TypeinterventionalSponsorHacettepe UniversityRan2026 to 2027Enrolled45ConditionsFibromyalgia, Fibromyalgia (FM), Fibromyalgia Syndrome, PrimaryArmsMedical Nutrition Therapy (MNT), Hardaliye (200 mL/day)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  18. The Intersection of Sarcopenia and Musculoskeletal Pain: Addressing Interconnected Challenges in Aging Care.International journal of environmental research and public health · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilenia Casini *Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Valeria Ladisa *Neurophysiopathology Unit, DiBrain Department, Policlinico General Hospital, Bari Aldo Moro University, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Livio ClementeNeurophysiopathology Unit, DiBrain Department, Policlinico General Hospital, Bari Aldo Moro University, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Marianna DelussiNeurophysiopathology Unit, DiBrain Department, Policlinico General Hospital, Bari Aldo Moro University, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Elvira RostanzoDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Sofia PepariniDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Anna Maria Aloisi *Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Marina de Tommaso *Neurophysiopathology Unit, DiBrain Department, Policlinico General Hospital, Bari Aldo Moro University, Piazza Giulio Cesare 11, 70124, Bari, Italy. marina.detommaso@uniba.it.ORCID http://orcid.org/0000-0001-6567-5373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFibromyalgia is a form of chronic pain that affects a large number of women. It can start at any age and last a lifetime, with no cure. The Mediterranean diet is said to have an anti-inflammatory effect. Therefore, this study was conducted to investigate possible beneficial effects of a personalized Mediterranean diet in patients with fibromyalgia.

methodsOutpatients with fibromyalgia were recruited and invited to participate in the study, including clinical, nutritional, and dietary assessments. Patients received a personalized Mediterranean diet (DIET group) or a general balanced diet (NODIET group) to be followed for 8 weeks. All tests were carried out at baseline and repeated after 4 and 8 weeks.

resultsIn total, 100 subjects were included, 84 of whom completed the study. Most of the patients showed incorrect habits in terms of food choices, timing of meals and composition of nutrients. The DIET group showed an improvement in most of the fibromyalgia parameters, including the disability scores, fatigue, and anxiety.

conclusionsThe habit of eating inflammatory foods and/or eating meals with the wrong nutritional content would increase the negative status of patients with fibromyalgia. With this study, we confirm that proper attention to feeding habits would improve the quality of life of such patients.

Indexed as

DietFibromyalgiaInflammationMediterraneanPain

Identifiers

PMID38683449
PMCPMC11111631

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.