ArticlePhysiological reports2024
Effects of maternal exercise on infant mesenchymal stem cell mitochondrial function, insulin action, and body composition in infancy.
Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Exercise FITT-V during pregnancy: dose-dependent reduction in infant cellular lipid content and whole body fat.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Maternal exercise alters placental proteome in an exercise mode-specific manner.American journal of physiology. Endocrinology and metabolism · 2025Trial
- Effects of maternal exercise modes on infant cord blood proteome.Physiological reports · 2025Trial
- Maternal resistance exercise increases infant energy expenditure.American journal of physiology. Endocrinology and metabolism · 2025Trial
- Paternal obesity decreases infant MSC mitochondrial functional capacity.American journal of physiology. Endocrinology and metabolism · 2024Trial
- Maternal exercise increases infant resting energy expenditure: preliminary results.International journal of obesity (2005) · 2024Trial
- Skeletal muscle mitochondrial bioenergetics in pregnancy: a comparison of in vivo and in vitro outcomes.Journal of the Endocrine Society · 2026Article
- Parental exercise mediates fetal metabolic and cardiac programming.Nature reviews. Endocrinology · 2026Review
- The metabolic implications of maternal exercise: effects on pregnant women and their offspring.Frontiers in nutrition · 2026Review
- Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques.Scientific reports · 2025Article
- Effect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism.American journal of physiology. Endocrinology and metabolism · 2025Article
- Exercise benefits yourself and your offspring: a mini-review.Frontiers in cell and developmental biology · 2025Review
- Exercise during pregnancy modulates infant cellular and whole-body adiposity.Physiological reports · 2024Article
- Early Life Energy Balance: The Development of Infant Energy Expenditure and Intake in the Context of Obesity.Current obesity reports · 2024Review
- Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity.Current diabetes reports · 2024Review
- Effects of maternal exercise on infant mesenchymal stem cell mitochondrial function, insulin action, and body composition in infancy.Physiological reports · 2024Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Maternal exercise (ME) has been established as a useful non-pharmacological intervention to improve infant metabolic health; however, mechanistic insight behind these adaptations remains mostly confined to animal models. Infant mesenchymal stem cells (MSCs) give rise to infant tissues (e.g., skeletal muscle), and remain involved in mature tissue maintenance. Importantly, these cells maintain metabolic characteristics of an offspring donor and provide a model for the investigation of mechanisms behind infant metabolic health improvements. We used undifferentiated MSC to investigate if ME affects infant MSC mitochondrial function and insulin action, and if these adaptations are associated with lower infant adiposity. We found that infants from exercising mothers have improvements in MSC insulin signaling related to higher MSC respiration and fat oxidation, and expression and activation of energy-sensing and redox-sensitive proteins. Further, we found that infants exposed to exercise in utero were leaner at 1 month of age, with a significant inverse correlation between infant MSC respiration and infant adiposity at 6 months of age. These data suggest that infants from exercising mothers are relatively leaner, and this is associated with higher infant MSC mitochondrial respiration, fat use, and insulin action.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.