Evidence map›Paper›PMID 38686266›Full record

ArticleCureus2024

Multicenter Study on Breast Cancer in the Geriatric Population: Insights for Effective Treatment Strategies.

Sule Karabulut Gul, Huseyin Tepetam, Berrin Benli Yavuz, Ozge Kandemir Gursel, Ayşe Altinok, Pelin Altinok, Ahmet Fatih Oruc, Duygu Akincioglu, Raghad Al Shomali, Omar Alomari and 1 more

Abstract read
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sule Karabulut GulRadiation Oncology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, TUR.
Huseyin TepetamRadiation Oncology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, TUR.
Berrin Benli YavuzRadiation Oncology, Meram Medical Faculty - Necmettin Erbakan University, Konya, TUR.
Ozge Kandemir GurselRadiation Oncology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, TUR.
Ayşe AltinokRadiation Oncology, Medical Park Hospital, Istanbul, TUR.
Pelin AltinokRadiation Oncology, Umraniye Training and Research Hospital, Istanbul, TUR.
Ahmet Fatih OrucRadiation Oncology, Istanbul Oncology Hospital, Istanbul, TUR.
Duygu AkinciogluRadiation Oncology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, TUR.
Raghad Al ShomaliRadiation Oncology, Hamidiye International School of Medicine, University of Health Sciences, Istanbul, TUR.
Omar AlomariRadiation Oncology, Hamidiye International School of Medicine, University of Health Sciences, Istanbul, TUR.
Mehmet Alper KayaRadiation Oncology, Hamidiye International School of Medicine, University of Health Sciences, Istanbul, TUR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBreast cancer is common among women aged 65 and over. There is a significant lack of evidence regarding the treatment of breast cancer in patients in this age group due to the rare inclusion of these patients in clinical studies. However, it is known that survival in elderly patients with breast cancer is significantly reduced in those not receiving standard therapy. Several factors, including patients' comorbidities, performance status, life expectancy, and tumor pathological and molecular characteristics, can affect the outcomes of treatment. In this study, we aimed to update the knowledge in this field by assessing these factors among the geriatric population in our multicenter dataset.

methodsThis retrospective study analyzed data from 335 breast cancer patients aged 65 and over who received adjuvant radiotherapy at five oncology centers (Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Meram Medical Faculty - Necmettin Erbakan University, Konya, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Umraniye Training and Research Hospital, Istanbul, and Istanbul Oncology Hospital, Istanbul) between May 2010 and September 2022. Demographic, clinical, and pathological data were collected, including age, gender, clinical symptoms, tumor characteristics, treatment approaches, and outcomes. Statistical analyses, including descriptive statistics, Kaplan-Meier analysis, log-rank test, and Cox regression analysis, were performed using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States), with a significance level of p < 0.05.

resultsThe tumor characteristics and survival time of 335 breast cancer patients were examined. In the results, performance status, T stage, and perineural invasion were found to be factors affecting the survival of elderly breast cancer patients. In multivariate analysis, it was seen that performance status played an important role as an independent prognostic factor.

conclusionThe treatment of breast cancer in the geriatric age group necessitates a personalized approach, taking into account the patient's overall health status, life expectancy, and comorbidities.

Indexed as

breast cancerelderly patientsmulticenter analysismulticenter studytreatment approaches

Identifiers

PMID38686266
PMCPMC11057335

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.