Evidence map›Paper›PMID 38686434›Full record

ReviewAdvanced healthcare materials2024

Tissue-Engineered Microvessels: A Review of Current Engineering Strategies and Applications.

Nan Zhao, Alexander F Pessell, Ninghao Zhu, Peter C Searson

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. 4D force patterning enables spatial control of angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nan ZhaoInstitute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Alexander F PessellDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Ninghao ZhuInstitute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Peter C SearsonInstitute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-5417-0828

Funding

Mechanisms of cerebrovascular barrier dysfunction caused by APP and PSEN1 mutations and amyloid beta exposureR01NS106008 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SEARSON, PETER C · 2019 to 2023
$1.9M
Engineering three-dimensional perfusable microphysiological models of the human inner blood-retina barrierR01EY035853 · NEI · DUKE UNIVERSITY · PI Sharon Gerecht · 2024 to 2026
$1.9M
Reverse engineering zonation-specific and age-specific iPSC-derived cerebrovascular models based on transcriptomic profiling of the human brainR61HL154252 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HEIMAN, MYRIAM, SEARSON, PETER C · 2021 to 2022
$1.6M
Reverse engineering zonation-specific and age-specific iPSC-derived cerebrovascular models based on transcriptomic profiling of the human brainR33HL154252 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HEIMAN, MYRIAM, SEARSON, PETER C · 2023 to 2025
$1.3M
Elucidating the role of pericytes in angiogenesis in the brain using a tissue-engineered microvessel modelR21NS131831 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SEARSON, PETER C · 2023 to 2024
$450k
NEI NIH HHS R01 EY035853NHLBI NIH HHS R33 HL154252NHLBI NIH HHS R61 HL154252NIH HHS R01NS106008NIH HHS R21NS131831NIH HHS R61 HL154252NINDS NIH HHS R01 NS106008NINDS NIH HHS R21 NS131831NSF DGE2139757
6 · The paper itself

Abstract

Microvessels, including arterioles, capillaries, and venules, play an important role in regulating blood flow, enabling nutrient and waste exchange, and facilitating immune surveillance. Due to their important roles in maintaining normal function in human tissues, a substantial effort has been devoted to developing tissue-engineered models to study endothelium-related biology and pathology. Various engineering strategies have been developed to recapitulate the structural, cellular, and molecular hallmarks of native human microvessels in vitro. In this review, recent progress in engineering approaches, key components, and culture platforms for tissue-engineered human microvessel models is summarized. Then, tissue-specific models, and the major applications of tissue-engineered microvessels in development, disease modeling, drug screening and delivery, and vascularization in tissue engineering, are reviewed. Finally, future research directions for the field are discussed.

Indexed as

MicrovesselsTissue EngineeringAnimalsHumansNeovascularization, Physiologicendothelial cellmicrovesselstissue‐engineering

Identifiers

PMID38686434
PMCPMC11338730

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.