Evidence map›Paper›PMID 38687642›Full record

ArticleCell reports2024

ER-associated degradation adapter Sel1L is required for CD8

Luis O Correa-Medero, Shayna E Jankowski, Hanna S Hong, Nicholas D Armas, Aditi I Vijendra, Mack B Reynolds, Garrett M Fogo, Dominik Awad, Alexander T Dils, Kantaro A Inoki and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Time-resolved photocatalytic proximity labeling uncovers ER proteome dynamics underlying UPR-to-apoptosis transition.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. SEL1L-HRD1-mediated ERAD in mammals.Nature cell biology · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Luis O Correa-MederoGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Shayna E JankowskiUniversity of Michigan, Ann Arbor, MI 48109, USA.
Hanna S HongGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Nicholas D ArmasGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Aditi I VijendraUniversity of Michigan, Ann Arbor, MI 48109, USA.
Mack B ReynoldsGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Garrett M FogoNeuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Dominik AwadDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Alexander T DilsDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kantaro A InokiUniversity of Michigan, Ann Arbor, MI 48109, USA.
Reid G WilliamsGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Annabelle M YeUniversity of Michigan, Ann Arbor, MI 48109, USA.
Nadezhda SvezhovaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Francisco Gomez-RiveraGraduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Kathleen L CollinsDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Mary X O'RiordanDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas H SandersonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Shannon A CartyDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: scarty@umich.edu.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Proteogenomics of Cancer Training ProgramT32CA140044 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, ARVIND, SARTOR, MAUREEN AGNES · 2010 to 2024
$3.9M
Non-invasive mitochondrial modulation therapy for ischemic strokeR01NS120322 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2021 to 2025
$2.3M
The role for ER associated degradation (ERAD) in T cell homeostasis and memoryR01AI165533 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shannon A. Carty · 2023 to 2026
$2.2M
Mitochondrial stress shapes host responses to bacterial infectionR01AI157384 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'RIORDAN, MARY · 2021 to 2025
$2.0M
Exploring the mechanisms of dysfunctional mitochondrial quality control in cerebrovascular disease and the aging brainF99AG079793 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOGO, GARRETT MCGUIRE · 2022 to 2024
$60k
Investigating mitochondrial dynamics in cerebral ischemia/reperfusion injury using novel morphological analyses and computational modelingF31NS124280 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOGO, GARRETT MCGUIRE · 2021 to 2021
$38k
NCI NIH HHS P30 CA046592NCI NIH HHS T32 CA140044NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI157384NIAID NIH HHS R01 AI165533NIAID NIH HHS T32 AI007413NIA NIH HHS F99 AG079793NIDA NIH HHS 75N95020D00005NINDS NIH HHS F31 NS124280NINDS NIH HHS R01 NS120322ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

The maintenance of antigen-specific CD8

Indexed as

CD8-Positive T-LymphocytesEndoplasmic Reticulum-Associated DegradationEndoplasmic Reticulum StressImmunologic MemoryAcute DiseaseAnimalsFemaleHumansIntracellular Signaling Peptides and ProteinsLymphocytic ChoriomeningitisMaleMiceMice, Inbred C57BLProteinsRNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsProteinsRNA-Binding ProteinsSel1h protein, mouseSEL1L protein, humanCD8 T cellCP: ImmunologyERADER stressimmunometabolismMycprotein homeostasisT cell memory

Identifiers

PMID38687642
PMCPMC11194752
OpenAlexW4396242312

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.