Evidence map›Paper›PMID 38688358›Full record

ArticleCells & development2024

Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis.

Kuang-Ling Ou, Chih-Kuan Chen, Junxiang J Huang, William Weijen Chang, Shu-Man Hsieh Li, Ting-Xin Jiang, Randall B Widelitz, Rusty Lansford, Cheng-Ming Chuong

Abstract read
In one paragraph

Article in Cells & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kuang-Ling OuDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Ostrow School of Dentistry of the University of Southern California, Los Angeles, CA, United States of America; Burn Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Chih-Kuan ChenDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America.
Junxiang J HuangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA, United States of America; Graduate Programs in Biomedical and Biological Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
William Weijen ChangDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Integrative Stem Cell Center, China Medical University, Taichung, Taiwan; Institute of Physiology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Shu-Man Hsieh LiDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Ostrow School of Dentistry of the University of Southern California, Los Angeles, CA, United States of America.
Ting-Xin JiangDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America.
Randall B WidelitzDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America.
Rusty LansfordDepartment of Radiology and Developmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, United States of America; Department of Radiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America.
Cheng-Ming ChuongDepartment of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America. Electronic address: cmchuong@med.usc.edu.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CARYN LERMAN · 1985 to 2026
$181.4M
USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOLDEN, LUCY MARY · 1995 to 2020
$21.8M
Size regulation of skin appendagesR01AR047364 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2002 to 2026
$10.1M
Tissue Engineering of New Hair FormationR01AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 2010 to 2019
$4.6M
Tissue Patterning in living skin and organ explantsR37AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2020 to 2026
$3.6M
5 D impulse mapping in the embryonic heartR01HL167159 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ANDREW Martin ROLLINS · 2023 to 2026
$2.7M
Multi-scale modulation of organ adaptationR35GM153402 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2024 to 2026
$1.2M
NCI NIH HHS P30 CA014089NHLBI NIH HHS R01 HL167159NIAMS NIH HHS R01 AR047364NIAMS NIH HHS R01 AR060306NIAMS NIH HHS R37 AR060306NIDDK NIH HHS P30 DK048522NIGMS NIH HHS R35 GM153402
6 · The paper itself

Abstract

A vasculature network supplies blood to feather buds in the developing skin. Does the vasculature network during early skin development form by sequential sprouting from the central vasculature or does local vasculogenesis occur first that then connect with the central vascular tree? Using transgenic Japanese quail Tg(TIE1p.H2B-eYFP), we observe that vascular progenitor cells appear after feather primordia formation. The vasculature then radiates out from each bud and connects with primordial vessels from neighboring buds. Later they connect with the central vasculature. Epithelial-mesenchymal recombination shows local vasculature is patterned by the epithelium, which expresses FGF2 and VEGF. Perturbing noggin expression leads to abnormal vascularization. To study endothelial origin, we compare transcriptomes of TIE1p.H2B-eYFP

Indexed as

Neovascularization, PhysiologicSkinAnimalsAnimals, Genetically ModifiedCell DifferentiationChick EmbryoCoturnixDermisEndothelial CellsFeathersGene Expression Regulation, DevelopmentalMesodermEndotheliumFeatherMesenchymal stem cellsNeovascularizationPattern formationTransgenic quail

Identifiers

PMID38688358
PMCPMC11633821

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.