Evidence map›Paper›PMID 38689090›Full record

ReviewExperimental & molecular medicine2024

Paradigm shift required for translational research on the brain.

Jong Hyuk Yoon, Dongha Lee, Chany Lee, Eunji Cho, Seulah Lee, Amaury Cazenave-Gassiot, Kipom Kim, Sehyun Chae, Edward A Dennis, Pann-Ghill Suh

Abstract readReview
In one paragraph

Review in Experimental & molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jong Hyuk Yoon *Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea. jhyoon@kbri.re.kr.ORCID http://orcid.org/0000-0002-4090-3832
Dongha Lee *Cognitive Science Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.
Chany Lee *Cognitive Science Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.
Eunji Cho *Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.ORCID http://orcid.org/0000-0002-9589-3643
Seulah LeeNeurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.
Amaury Cazenave-GassiotDepartment of Biochemistry and Precision Medicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.ORCID http://orcid.org/0000-0002-3050-634X
Kipom KimResearch Strategy Office, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.
Sehyun ChaeNeurovascular Unit Research Group, Korean Brain Research Institute, Daegu, 41062, Republic of Korea.
Edward A DennisDepartment of Pharmacology and Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093-0601, USA.ORCID http://orcid.org/0000-0003-3738-3140
Pann-Ghill SuhKorea Brain Research Institute, Daegu, 41062, Republic of Korea.

Funding

Action of Lipolytic EnzymesR35GM139641 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EDWARD A DENNIS · 2021 to 2026
$2.6M
NIGMS NIH HHS R35 GM139641
6 · The paper itself

Abstract

Biomedical research on the brain has led to many discoveries and developments, such as understanding human consciousness and the mind and overcoming brain diseases. However, historical biomedical research on the brain has unique characteristics that differ from those of conventional biomedical research. For example, there are different scientific interpretations due to the high complexity of the brain and insufficient intercommunication between researchers of different disciplines owing to the limited conceptual and technical overlap of distinct backgrounds. Therefore, the development of biomedical research on the brain has been slower than that in other areas. Brain biomedical research has recently undergone a paradigm shift, and conducting patient-centered, large-scale brain biomedical research has become possible using emerging high-throughput analysis tools. Neuroimaging, multiomics, and artificial intelligence technology are the main drivers of this new approach, foreshadowing dramatic advances in translational research. In addition, emerging interdisciplinary cooperative studies provide insights into how unresolved questions in biomedicine can be addressed. This review presents the in-depth aspects of conventional biomedical research and discusses the future of biomedical research on the brain.

Indexed as

BrainTranslational Research, BiomedicalAnimalsArtificial IntelligenceBiomedical ResearchBrain DiseasesHumansNeuroimaging

Identifiers

PMID38689090
PMCPMC11148129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.