Evidence map›Paper›PMID 38689935›Full record

ReviewFrontiers in nutrition2024

Recent insights into breast milk microRNA: their role as functional regulators.

Yi-Ran Xu, Jinglu Zhao, Hsi-Yuan Huang, Yang-Chi-Dung Lin, Tzong-Yi Lee, Hsien-Da Huang, Yi Yang, Yong-Fei Wang

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Comparative analysis of microRNAs in bovine colostrum and neonatal calf blood.Journal of the science of food and agriculture · 2026
    Article
  3. Observational
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi-Ran XuWarshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Jinglu ZhaoWarshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Hsi-Yuan HuangWarshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Yang-Chi-Dung LinWarshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Tzong-Yi LeeInstitute of Bioinformatics and Systems Biology and Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Hsien-Da HuangWarshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
Yi YangDepartment of Nephrology, Center for Regeneration and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Yong-Fei WangWarshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast milk (BM) is a primary biofluid that plays a crucial role in infant development and the regulation of the immune system. As a class of rich biomolecules in BM, microRNAs (miRNAs) are regarded as active factors contributing to infant growth and development. Surprisingly, these molecules exhibit resilience in harsh conditions, providing an opportunity for infants to absorb them. In addition, many studies have shown that miRNAs in breast milk, when absorbed into the gastrointestinal system, can act as a class of functional regulators to effectively regulate gene expression. Understanding the absorption pattern of BM miRNA may facilitate the creation of formula with a more optimal miRNA balance and pave the way for novel drug delivery techniques. In this review, we initially present evidence of BM miRNA absorption. Subsequently, we compile studies that integrate both

Indexed as

breast milkdigestive systemimmune systeminfant developmentmiRNA

Identifiers

PMID38689935
PMCPMC11058965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.