Evidence map›Paper›PMID 38690127›Full record

ArticleJBMR plus2024

Collagen mutation and age contribute to differential craniofacial phenotypes in mouse models of osteogenesis imperfecta.

Hsiao H Sung, Wyatt J Spresser, Joseph P Hoffmann, Zongrui Dai, Peter M Van der Kraan, Michelle S Caird, Esmeralda Blaney Davidson, Kenneth M Kozloff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Hsiao H SungOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, United States.ORCID https://orcid.org/0000-0001-6016-3838
Wyatt J SpresserDepartment of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109, United States.
Joseph P HoffmannDepartment of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109, United States.
Zongrui DaiDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, United States.
Peter M Van der KraanExperimental Rheumatology, Department of Rheumatology, Radboud Medical Centre, Nijmegen, The Netherlands, 6525 GA.
Michelle S CairdOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, United States.
Esmeralda Blaney DavidsonExperimental Rheumatology, Department of Rheumatology, Radboud Medical Centre, Nijmegen, The Netherlands, 6525 GA.
Kenneth M KozloffOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, United States.ORCID https://orcid.org/0000-0002-1108-7258
University of Michigan · USRadboud University Nijmegen · NL

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Biomarking the Sclerostin Antibody Effects on Osseointegration in an Osteogenesis Imperfecta ModelK08DE030116 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG HSIEH, HSIAO HSIN · 2021 to 2024
$600k
In Vivo Micro-Computed Tomography Imaging SystemS10OD017979 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOZLOFF, KENNETH M · 2015 to 2015
$393k
Biologic signatures for sclerostin antibody responsiveness in human and murine models of osteogenesis imperfectaR21AR075197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOZLOFF, KENNETH M · 2019 to 2020
$378k
NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R21 AR075197NIDCR NIH HHS K08 DE030116NIH HHS S10 OD017979
6 · The paper itself

Abstract

Craniofacial and dentoalveolar abnormalities are present in all types of osteogenesis imperfecta (OI). Mouse models of the disorder are critical to understand these abnormalities and underlying OI pathogenesis. Previous studies on severely affected OI mice report a broad spectrum of craniofacial phenotypes, exhibiting some similarities to the human disorder. The Brtl/+ and G610c/+ are moderately severe and mild-type IV OI, respectively. Little is known about the aging effects on the craniofacial bones of these models and their homology to human OI. This study aimed to analyze the Brtl/+ and G610c/+ craniofacial morphometries during aging to establish suitability for further OI craniofacial bone intervention studies. We performed morphological measurements on the micro-CT-scanned heads of 3-wk-old, 3-mo-old, and 6-mo-old female Brtl/+ and G610c/+ mice. We observed that Brtl/+ skulls are shorter in length than WT (

Indexed as

alveolar bonemandiblemaxillamicro-CT imagingosteogenesis imperfectateeth

Identifiers

PMID38690127
PMCPMC11059998
OpenAlexW4390531694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.