ArticleEnvironmental science & technology2024
Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts.
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Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Untargeted Lipidomics Analysis of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Small-for-Gestational Age (SGA) Delivery: An Exploratory Study in the Atlanta African American Maternal-Child Cohort, 2014-2020.Environmental health perspectives · 2026Article
- Activation of anti-inflammatory pathways by polyunsaturated fatty acid signaling may protect neurodevelopment in children prenatally exposed to methylmercury.Environmental health : a global access science source · 2026Article
- Associations between prenatal per- and polyfluoroalkyl substances (PFAS) and repeated measures of bioactive lipids during pregnancy in the LIFECODES cohort.The Science of the total environment · 2026Article
- Gestational PFAS concentrations in association with maternal depression and perceived stress during pregnancy and postpartum in the ECHO cohort.Environmental research · 2025Article
- Fetal response to maternal exposures of environmental chemicals: Utility of a four-cell human feto-maternal interface organ-on-chip.Chemico-biological interactions · 2025Article
- Assessment of per- and polyfluoroalkyl substances (PFAS) exposure and associations with oxidative stress biomarkers among pregnant women from the PROTECT cohort.The Science of the total environment · 2025Article
- Association of per- and polyfluoroalkyl substances with the antioxidant bilirubin across pregnancy.Free radical biology & medicine · 2024Article
Corrections and comments
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Authors and funding
33 authors at 12 institutions in 2 countries.
Himal SutharDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California 90032, United States.
Tomás ManeaDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California 90032, United States.
Dominic PakDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California 90032, United States.
Megan WoodburyDepartment of Civil and Environmental Engineering, Northeastern University, Boston, Massachusetts 02115, United States.
Stephanie M EickGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, Georgia 30322, United States.ORCID 0000-0001-6695-3291
Amber CatheyDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States.
Deborah J WatkinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States.
Rita S StrakovskyInstitute for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, United States.
Brad A RyvaInstitute for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, United States.
Subramaniam PennathurDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, Michigan 48824, United States.ORCID 0000-0003-3628-6883
Lixia ZengDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, Michigan 48824, United States.
David WellerNSF International, Ann Arbor, Michigan 48105, United States.
June-Soo ParkEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United States.ORCID 0009-0005-2177-4405
Sabrina SmithEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, California 94710, United States.
Erin DeMiccoProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, California 94143, United States.
Amy PadulaProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, California 94143, United States.
Rebecca C FryDepartment of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina 27599, United States.
Bhramar MukherjeeDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States.
Andrea AguiarBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Champaign, Illinois 61801, United States.
Sarah Dee GeigerDepartment of Comparative Biosciences, University of Illinois Urbana-Champaign, Champaign, Illinois 61802, United States.
Shukhan NgDepartment of Comparative Biosciences, University of Illinois Urbana-Champaign, Champaign, Illinois 61802, United States.
Gredia Huerta-MontanezDepartment of Civil and Environmental Engineering, Northeastern University, Boston, Massachusetts 02115, United States.
Carmen Vélez-VegaDepartment of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia 30606, United States.
Zaira RosarioUniversity of Puerto Rico Graduate School of Public Health, San Juan, Puerto Rico 00935, United States.
Jose F CorderoDepartment of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia 30606, United States.
Emily ZimmermanDepartment of Communication Sciences and Disorders, Northeastern University, Boston, Massachusetts 02115, United States.
Tracey J WoodruffProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, California 94143, United States.ORCID 0000-0003-3622-1297
Rachel Morello-FroschProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, California 94143, United States.
Susan L SchantzBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Champaign, Illinois 61801, United States.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States.
Akram N AlshawabkehDepartment of Civil and Environmental Engineering, Northeastern University, Boston, Massachusetts 02115, United States.
Max T AungDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, California 90032, United States.ORCID 0000-0001-5541-5447
Program Collaborators for Environmental Influences on Child Health Outcomes
University of Michigan · USNortheastern University · USUniversity of California, San Francisco · USUniversity of Illinois Urbana-Champaign · USUniversity of Southern California · USCalifornia Environmental Protection Agency · USMichigan State University · USUniversity of Georgia · USEmory University · USNational Sanitation Foundation International · USUniversity of North Carolina at Chapel Hill · USUniversity of Puerto Rico System · PR
Funding
Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI JUNFENG ZHANG · 2016 to 2026
$215.9MECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4MTranslational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MThe ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7MResearch Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI HARRIS, SEAN M · 2010 to 2024
$38.6MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MEnvironmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)UH3OD023251 · OD · NORTHEASTERN UNIVERSITY · PI Akram N Alshawabkeh · 2018 to 2026
$24.0MPilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3MThe Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6MUCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rashmi Joglekar · 2020 to 2026
$11.2MNIDDK NIH HHS P30 DK089503NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P01 ES022848NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P30 ES030284NIEHS NIH HHS P42 ES017198NIEHS NIH HHS P50 ES026049NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UH3 OD023251NIH HHS UH3 OD023272
Abstract
Prenatal per- and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipids─metabolic and inflammation pathway indicators. We estimated associations between prenatal PFAS exposure and bioactive lipids, measuring 12 serum PFAS and 50 plasma bioactive lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained through linear mixed models and meta-analysis, adjusting the former for false discovery rates. Associations between the PFAS mixture and bioactive lipids were estimated using quantile g-computation. Pairwise analyses revealed bioactive lipid levels associated with PFDeA, PFNA, PFOA, and PFUdA (
Indexed as
FluorocarbonsLipidsAdultChildChild HealthCohort StudiesCross-Sectional StudiesEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaternal ExposurePregnancyEnvironmental PollutantsFluorocarbonsLipidsbioactive lipidseicosanoidsinflammatory pathwaysmetabolic pathwaysmixturesPFASpregnancy outcomes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.