Evidence map›Paper›PMID 38692734›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.

Francesca W van Tartwijk, Lucia C S Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian A H Jakobs, Seema Qamar, Kristian Franze, Gabriele S Kaminski Schierle, Peter H St George-Hyslop, Julie Qiaojin Lin and 2 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Discovery of TDP-43 aggregation inhibitorsbioRxiv : the preprint server for biology · 2026
    Article
  4. CNP-induced cGMP signaling reduces growth cone stiffness and CaFrontiers in molecular neuroscience · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Francesca W van TartwijkDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0002-9795-2571
Lucia C S WunderlichDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0001-7200-1713
Ioanna MelaDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0002-2914-9971
Stanislaw MakarchukDepartment of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge CB2 OAH, United Kingdom.ORCID 0000-0001-5484-7141
Maximilian A H JakobsDepartment of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom.ORCID 0000-0002-0879-7937
Seema QamarDepartment of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Kristian FranzeDepartment of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom.ORCID 0000-0002-8425-7297
Gabriele S Kaminski SchierleDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0002-1843-2202
Peter H St George-HyslopDepartment of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID 0000-0003-0796-7209
Julie Qiaojin LinDepartment of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge CB2 OAH, United Kingdom.ORCID 0000-0002-2669-6478
Christine E HoltDepartment of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom.ORCID 0000-0003-2829-121X
Clemens F KaminskiDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom cfk23@cam.ac.uk.ORCID 0000-0002-5194-0962
University of Cambridge · GBKing's College London · GBUK Dementia Research Institute · GBUniversity Health Network · CA

Funding

European Research Council 772426Medical Research Council MR/K015850/1Medical Research Council MR/K02292X/1Wellcome Trust 109145Wellcome Trust 215943
6 · The paper itself

Abstract

Aberrant condensation and localization of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with changes in axonal cytoskeletal organization and branching in neurodevelopmental disorders. Here, we asked whether branching defects also occur in vivo in a model of FUS-associated disease. We use two reported

Indexed as

Amyotrophic Lateral SclerosisAxonsFrontotemporal DementiaMutationRNA-Binding Protein FUSAnimalsDisease Models, AnimalFemaleGrowth ConesHumansMaleXenopus laevisRNA-Binding Protein FUSALS/FTDaxonal branchingcytoskeletonFUSgrowth coneneurodevelopment

Identifiers

PMID38692734
PMCPMC7616130
OpenAlexW4396569658

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.