ArticleProceedings of the National Academy of Sciences of the United States of America2024
DELLA proteins recruit the Mediator complex subunit MED15 to coactivate transcription in land plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Genomic early growth mechanisms of two endangered Mexican spruces.BMC plant biology · 2026Article
- Evolutionary shifts in plant adaptation mediated by phytohormones.Plant communications · 2026Review
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- INDETERMINATE DOMAIN-DELLA protein interactions orchestrate gibberellin-mediated cell elongation in wheat and barley.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification of DELLA and GID1 genes in Catharanthus roseus and their potential role in regulating vindoline biosynthesis.Plant molecular biology · 2025Article
- Green Revolution DELLA Proteins: Functional Analysis and Regulatory Mechanisms.Annual review of plant biology · 2025Review
- Collaboration between DELLA proteins and the Mediator subunit MED15 to regulate transcription in plants.Journal of experimental botany · 2025Article
- Evolutionary origins and functional diversification of Auxin Response Factors.Nature communications · 2024Article
- Current and future perspectives for enhancing our understanding of the evolution of plant metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Phylogeny and evolution of streptophyte algae.Annals of botany · 2024Review
- DELLA proteins recruit the Mediator complex subunit MED15 to coactivate transcription in land plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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9 authors.
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Abstract
DELLA proteins are negative regulators of the gibberellin response pathway in angiosperms, acting as central hubs that interact with hundreds of transcription factors (TFs) and regulators to modulate their activities. While the mechanism of TF sequestration by DELLAs to prevent DNA binding to downstream targets has been extensively documented, the mechanism that allows them to act as coactivators remains to be understood. Here, we demonstrate that DELLAs directly recruit the Mediator complex to specific loci in Arabidopsis, facilitating transcription. This recruitment involves DELLA amino-terminal domain and the conserved MED15 KIX domain. Accordingly, partial loss of MED15 function mainly disrupted processes known to rely on DELLA coactivation capacity, including cytokinin-dependent regulation of meristem function and skotomorphogenic response, gibberellin metabolism feedback, and flavonol production. We have also found that the single DELLA protein in the liverwort
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