Evidence map›Paper›PMID 38698671›Full record

ArticleJournal of neurotrauma2024

Distinct Serum Glial Fibrillary Acidic Protein and Neurofilament Light Time-Courses After Rapid Head Rotations.

Colin M Huber, Akshara D Thakore, R Anna Oeur, Susan S Margulies

Abstract read
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Colin M HuberWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Atlanta, Atlanta, Georgia, USA.ORCID 0000-0002-0045-5940
Akshara D ThakoreWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Atlanta, Atlanta, Georgia, USA.
R Anna OeurWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Atlanta, Atlanta, Georgia, USA.ORCID 0000-0002-5587-3517
Susan S MarguliesWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Atlanta, Atlanta, Georgia, USA.ORCID 0000-0002-3615-7902

Funding

Biomechanics of Pediatric Head InjuryR01NS039679 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MARGULIES, SUSAN SHEPS · 2001 to 2011
$5.0M
Objective Translational Multi-domain Early Concussion AssessmentR01NS097549 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ARBOGAST, KRISTY, MARGULIES, SUSAN SHEPS · 2017 to 2021
$4.5M
PRECLINICAL CYCLOSPORIN A THERAPY TRIALS FOR PEDIATRIC TBIU01NS069545 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DUHAIME, ANN-CHRISTINE, MARGULIES, SUSAN SHEPS · 2011 to 2017
$3.5M
NINDS NIH HHS R01 NS039679NINDS NIH HHS R01 NS097549NINDS NIH HHS U01 NS069545
6 · The paper itself

Abstract

Traumatic brain injury (TBI) causes significant neurophysiological deficits and is typically associated with rapid head accelerations common in sports-related incidents and automobile accidents. There are over 1.5 million TBIs in the United States each year, with children aged 0-4 being particularly vulnerable. TBI diagnosis is currently achieved through interpretation of clinical signs and symptoms and neuroimaging; however, there is increasing interest in minimally invasive fluid biomarkers to detect TBI objectively across all ages. Pre-clinical porcine models offer controlled conditions to evaluate TBI with known biomechanical conditions and without comorbidities. The objective of the current study was to establish pediatric porcine healthy reference ranges (RRs) of common human serum TBI biomarkers and to report their acute time-course after nonimpact rotational head injury. A retrospective analysis was completed to quantify biomarker concentrations in porcine serum samples collected from 4-week-old female (

Indexed as

BiomarkersGlial Fibrillary Acidic ProteinNeurofilament ProteinsAnimalsBrain Injuries, TraumaticFemaleMaleReference ValuesRetrospective StudiesRotationSwineTime FactorsBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinspediatricserum biomarkersswinetraumatic brain injury

Identifiers

PMID38698671
PMCPMC11564843

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.