ArticleFrontiers in medicine2024
Albumin-to-alkaline phosphatase ratio as a novel prognostic indicator in patients undergoing peritoneal dialysis: a propensity score matching analysis.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Protecting peritoneal dialysis patients: evaluation and prevention strategies for noninfectious risk factors.Renal failure · 2026Review
- Employment of the Albumin to Alkaline Phosphatase Ratio to Predict All-cause Mortality and Cardiovascular and Cerebrovascular Mortality in Adults Aged At Least 60 Years: An Analysis From NHANES 2003-2018.Reviews in cardiovascular medicine · 2026Article
- The SII-PNI score: A novel composite biomarker for personalized mortality risk prediction in peritoneal dialysis patients.PloS one · 2025Article
- A study on the correlation between albumin-to-alkaline phosphatase ratio and the severity of pelvic inflammatory disease.Frontiers in medicine · 2025Article
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Authors and funding
5 authors.
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Abstract
Background: Though the albumin-to-alkaline phosphatase ratio (AAPR) is used as a biomarker in various diseases, little is known about its effect on outcomes after peritoneal dialysis (PD). Methods: This multicenter retrospective study comprised 357 incident PD patients stratified according to the AAPR. Propensity score matching (PSM) was performed to identify 85 patients for a well-matched comparison of all-cause and cardiovascular mortality. Using Cox regression, we performed univariate and multivariate analyses to investigate the prognostic value of the AAPR and established a Kaplan-Meier curve-predicted nomogram to estimate expected overall survival (OS). We assessed the predictive accuracy using the concordance index (c-index). Results: We found that the optimal cut-off of the AAPR to predict mortality was 0.36. In the present cohort of patients undergoing PD, a low AAPR strongly correlated with worse OS. In the multivariate analysis, the AAPR was shown to be an independent marker predicting reduced OS both before [hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.08-2.60, Conclusion: AAPR has potential as an independent prognostic biomarker in patients undergoing PD.
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