Evidence map›Paper›PMID 38698852›Full record

ArticleFrontiers in immunology2024

Aberrant CD8

Enitome E Bafor, Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E Kimmel, Olivier Duverger, John M Fenimore, Meredith Ramba, Thea Spindel, Megan M Hess and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Enitome E BaforCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Rebecca A Erwin-CohenCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Toni MartinCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Clayton BakerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.
Adrienne E KimmelCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Olivier DuvergerCraniofacial Anomalies and Regeneration Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States.
John M FenimoreCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Meredith RambaCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Thea SpindelCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Megan M HessCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Michael SanfordCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Vanja LazarevicExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States.
Bérénice A BenayounLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.
Howard A YoungCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.
Julio C ValenciaCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.

Funding

Control of Cytokine Gene Expression in LymphoidMyeloid CellsZIABC009283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOUNG, HOWARD · 2009 to 2024
$22.7M
Transcriptional regulation of inflammatory and autoimmune responsesZIABC011765 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2017 to 2025
$7.7M
Intramural NIH HHS ZIA BC009283
6 · The paper itself

Abstract

Introduction: Interferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive outcomes such as pregnancy failure or infertility. Additionally, the underlying immunological mechanisms remain elusive. Methods: Here, we explore the impact of systemic IFN-γ elevation on cytotoxic T cell responses in female reproduction utilizing a systemic lupus-prone mouse model with impaired IFN-γ degradation. Results: Our findings reveal that heightened IFN-γ levels triggered the infiltration of CD8 Discussion: These insights broaden our understanding of the role of elevated IFN-γ in female reproductive dysfunction and suggest CD8

Indexed as

CD8-Positive T-LymphocytesInterferon-gammaAnimalsDisease Models, AnimalFemaleInfertility, FemaleLupus Erythematosus, SystemicMiceMice, Inbred C57BLOvaryPituitary GlandPregnancyProlactinUterusIFNG protein, mouseInterferon-gammaProlactinCD8+ T cellshypophysitisimplantation failureinterferon-gamma (IFN-γ)luteinization defectpregnancyprolactin deficiencytissue-resident memory

Identifiers

PMID38698852
PMCPMC11064017

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.