Evidence map›Paper›PMID 38699344›Full record

ArticlemedRxiv : the preprint server for health sciences2024

A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.

Elizabeth B Stephens, Chatura Senadheera, Stephanie Roa-Diaz, Sawyer Peralta, Laura Alexander, Wendie Silverman-Martin, Michi Yukawa, Jenifer Morris, James B Johnson, John C Newman and 1 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Elizabeth B StephensBuck Institute for Research on Aging, Novato, CA, USA.
Chatura SenadheeraBuck Institute for Research on Aging, Novato, CA, USA.
Stephanie Roa-DiazBuck Institute for Research on Aging, Novato, CA, USA.
Sawyer PeraltaBuck Institute for Research on Aging, Novato, CA, USA.
Laura AlexanderBuck Institute for Research on Aging, Novato, CA, USA.
Wendie Silverman-MartinBuck Institute for Research on Aging, Novato, CA, USA.
Michi YukawaVeteran's Affairs Medical Center, San Francisco, CA, USA.
Jenifer MorrisBuck Institute for Research on Aging, Novato, CA, USA.
James B JohnsonIndependent Researcher, Greenbrae, CA, USA.
John C NewmanBuck Institute for Research on Aging, Novato, CA, USA.
Brianna J StubbsBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0001-9566-9134

Funding

Exogenous ketones target geroscience pathways and ameliorate geriatric syndromesK01AG078125 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Brianna Jane Stubbs · 2022 to 2026
$870k
NIA NIH HHS K01 AG078125
6 · The paper itself

Abstract

Bis-octanoyl (R)-1,3-butanediol (BO-BD) is a novel ketone ester (KE) ingredient which increases blood beta-hydroxybutyrate (BHB) concentrations rapidly after ingestion. KE is hypothesized to have beneficial metabolic effects on health and performance, especially in older adults. Whilst many studies have investigated the ketogenic effect of KE in young adults, they have not been studied in an exclusively older adult population, for whom age-related differences in body composition and metabolism may alter the effects. This randomized, observational, open-label study in healthy older adults (n = 30, 50% male, age = 76.5 years, BMI = 25.2 kg/m

Indexed as

beta-hydroxybutyrateexogenous ketoneketone di-esterketone esterketones

Identifiers

PMID38699344
PMCPMC11065008

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.