Evidence map›Paper›PMID 38700796›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2024

Advancing therapeutic efficacy: nanovesicular delivery systems for medicinal plant-based therapeutics.

Mohamed J Saadh, Mohammed Ahmed Mustafa, Sanjay Kumar, Pooja Gupta, Atreyi Pramanik, Jasur Alimdjanovich Rizaev, Hasanain Khaleel Shareef, Mahmood Hasen Shuhata Alubiady, Salah Hassan Zain Al-Abdeen, Hussein Ghafel Shakier and 2 more

RetractedAbstract readReviewRetracted Publication
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Bridging bioactive metabolites ofFrontiers in pharmacology · 2026
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mohamed J SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, Jordan. mstfhamdoo@gmail.com.
Mohammed Ahmed MustafaDepartment of Medical Laboratory Technology, University of Imam Jaafar AL-Sadiq, Baghdad, Iraq.
Sanjay KumarDepartment of Biotechnology and Genetics, Jain (Deemed-to-Be) University, Bengaluru, Karnataka, 560069, India.
Pooja GuptaSchool of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
Atreyi PramanikSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India.
Jasur Alimdjanovich RizaevDepartment of Public Health and Healthcare Management, Samarkand State Medical University, 18, Amir Temur Street, Rector, Samarkand, Uzbekistan.
Hasanain Khaleel ShareefDepartment of Medical Biotechnology, College of Science, Al-Mustaqbal University, Hilla, Iraq.
Mahmood Hasen Shuhata AlubiadyDepartment of Medical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq.
Salah Hassan Zain Al-AbdeenDepartment of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Hussein Ghafel ShakierCollege of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
Mohd AlarajFaculty of Pharmacy, Jerash Private University, Jerash, Jordan.
Laith H AlzubaidiCollege of Technical Engineering, The Islamic University, Najaf, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The utilization of medicinal plant extracts in therapeutics has been hindered by various challenges, including poor bioavailability and stability issues. Nanovesicular delivery systems have emerged as promising tools to overcome these limitations by enhancing the solubility, bioavailability, and targeted delivery of bioactive compounds from medicinal plants. This review explores the applications of nanovesicular delivery systems in antibacterial and anticancer therapeutics using medicinal plant extracts. We provide an overview of the bioactive compounds present in medicinal plants and their therapeutic properties, emphasizing the challenges associated with their utilization. Various types of nanovesicular delivery systems, including liposomes, niosomes, ethosomes, and solid lipid nanoparticles, among others, are discussed in detail, along with their potential applications in combating bacterial infections and cancer. The review highlights specific examples of antibacterial and anticancer activities demonstrated by these delivery systems against a range of pathogens and cancer types. Furthermore, we address the challenges and limitations associated with the scale-up, stability, toxicity, and regulatory considerations of nanovesicular delivery systems. Finally, future perspectives are outlined, focusing on emerging technologies, integration with personalized medicine, and potential collaborations to drive forward research in this field. Overall, this review underscores the potential of nanovesicular delivery systems for enhancing the therapeutic efficacy of medicinal plant extracts in antibacterial and anticancer applications, while identifying avenues for further research and development.

Indexed as

Anti-Bacterial AgentsPlant ExtractsPlants, MedicinalAnimalsAntineoplastic Agents, PhytogenicDrug Delivery SystemsHumansNanoparticle Drug Delivery SystemNanoparticlesNeoplasmsAnti-Bacterial AgentsAntineoplastic Agents, PhytogenicNanoparticle Drug Delivery SystemPlant ExtractsAntibacterial therapeuticsAnticancer therapeuticsMedicinal plant extractsNanovesicular delivery systemsTherapeutic optimization

Identifiers

PMID38700796

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.