Evidence map›Paper›PMID 38700926›Full record

ArticleeLife2024

The MODY-associated

Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The diabetes-associated KDiabetologia · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Arya Y NakheDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.ORCID https://orcid.org/0000-0003-2192-5865
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Jinsun KimDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Soma BeheraDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Jordyn R DobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Shristi ShresthaCenter for Stem Cell Biology, Vanderbilt University, Nashville, United States.
Jean-Philippe CartaillerCenter for Stem Cell Biology, Vanderbilt University, Nashville, United States.
Leesa SampsonCenter for Stem Cell Biology, Vanderbilt University, Nashville, United States.
Mark A MagnusonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.ORCID https://orcid.org/0000-0002-8824-6499
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.ORCID https://orcid.org/0000-0003-1816-5375

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Marcela Brissova · 2012 to 2026
$29.3M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Two-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3M
Molecular Mechanisms Regulating Pancreatic Delta Cell Function and DysfunctionR01DK129340 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2022 to 2026
$2.3M
Secretagogue and Gi/o-GPCR signaling through the islet Na+/K+-ATPase in health and diabetesR01DK136768 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2023 to 2026
$2.0M
Designing selective TALK-1 inhibitors to reduce beta-cell dysfunction in diabetesR01DK115620 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2018 to 2021
$1.6M
NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK115620NIDDK NIH HHS R01 DK129340NIDDK NIH HHS R01 DK136768NIDDK NIH HHS U2C DK059637NIH HHS R01DK097392NIH HHS R01DK115620NIH HHS R01DK129340
6 · The paper itself

Abstract

The gain-of-function mutation in the TALK-1 K

Indexed as

Diabetes Mellitus, Type 2GlucagonGlucoseInsulin SecretionMice, Inbred C57BLAnimalsAnimals, NewbornDisease Models, AnimalHomeostasisInsulinIslets of LangerhansMaleMiceMutationPotassium ChannelsPotassium Channels, Tandem Pore DomainGlucagonGlucoseInsulinKcnk16 protein, mousePotassium ChannelsPotassium Channels, Tandem Pore Domaincalciumcomputational biologydevelopmental biologyglucagoninsulinisletmonogenic diabetesmousesystems biologyTALK-1

Identifiers

PMID38700926
PMCPMC11068355

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.