Evidence map›Paper›PMID 38701355›Full record

ArticleDiabetes2024

Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.

Ibrahim Choucair, Deepthi P Mallela, James R Hilser, Jaana A Hartiala, Ina Nemet, Valentin Gogonea, Lin Li, Aldons J Lusis, Michael A Fischbach, W H Wilson Tang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ibrahim ChoucairDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Deepthi P MallelaDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
James R HilserDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jaana A HartialaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Ina NemetDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Valentin GogoneaDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Lin LiDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Aldons J LusisDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA.ORCID 0000-0001-9013-0228
Michael A FischbachDepartment of Bioengineering and ChEM-H, Stanford University, Stanford, CA.
W H Wilson TangDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Hooman AllayeeDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Stanley L HazenDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.ORCID 0000-0001-7124-6639

Funding

Gut microbial dietary phenylalanine metabolism and heart failureR01HL167831 · CLEVELAND CLINIC LERNER COM-CWRU · 2025 to 2025
$790k
Fondation Leducq 17CVD01NHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL133169NHLBI NIH HHS R01 HL148110NHLBI NIH HHS R01 HL167831NIDDK NIH HHS DP1 DK113598Office of Dietary Supplements DP1-DK113598
6 · The paper itself

Abstract

Bile acids (BAs) are cholesterol-derived compounds that regulate glucose, lipid, and energy metabolism. Despite their significance in glucose homeostasis, the association between specific BA molecular species and their synthetic pathways with diabetes is unclear. Here, we used a recently validated, stable-isotope dilution, high-performance liquid chromatography with tandem mass spectrometry method to quantify a panel of BAs in fasting plasma from 2,145 study participants and explored structural and genetic determinants of BAs linked to diabetes, insulin resistance, and obesity. Multiple 12α-hydroxylated BAs were associated with diabetes (adjusted odds ratio [aOR] range, 1.3-1.9; P < 0.05 for all) and insulin resistance (aOR range, 1.3-2.2; P < 0.05 for all). Conversely, multiple 6α-hydroxylated BAs and isolithocholic acid (iso-LCA) were inversely associated with diabetes and obesity (aOR range, 0.3-0.9; P < 0.05 for all). Genome-wide association studies revealed multiple genome-wide significant loci linked with 9 of the 14 diabetes-associated BAs, including a locus for iso-LCA (rs11866815). Mendelian randomization analyses showed genetically elevated deoxycholic acid levels were causally associated with higher BMI, and iso-LCA levels were causally associated with reduced BMI and diabetes risk. In conclusion, comprehensive, large-scale, quantitative mass spectrometry and genetics analyses show circulating levels of multiple structurally specific BAs, especially DCA and iso-LCA, are clinically associated with and genetically linked to obesity and diabetes. ARTICLE HIGHLIGHTS:

Indexed as

Bile Acids and SaltsGenome-Wide Association StudyInsulin ResistanceObesityAdultAgedDiabetes MellitusDiabetes Mellitus, Type 2FemaleHumansMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideBile Acids and Salts

Identifiers

PMID38701355
PMCPMC11262044

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.