Evidence map›Paper›PMID 38703095›Full record

ArticleHuman brain mapping2024

Characterization of tau propagation pattern and cascading hypometabolism from functional connectivity in Alzheimer's disease.

Min Wang, Jiaying Lu, Ying Zhang, Qi Zhang, Luyao Wang, Ping Wu, Matthias Brendel, Axel Rominger, Kuangyu Shi, Qianhua Zhao and 2 more

Abstract read
In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Min WangSchool of Life Sciences, Shanghai University, Shanghai, China.
Jiaying LuDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-0927-0042
Ying ZhangSchool of Life Sciences, Shanghai University, Shanghai, China.
Qi ZhangSchool of Life Sciences, Shanghai University, Shanghai, China.
Luyao WangSchool of Life Sciences, Shanghai University, Shanghai, China.
Ping WuDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Matthias BrendelDepartment of Nuclear Medicine, University of Munich, Munich, Germany.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Qianhua ZhaoNational Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Jiehui JiangSchool of Life Sciences, Shanghai University, Shanghai, China.ORCID 0000-0003-4948-3683
Chuantao ZuoDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-8856-7217

Funding

National Natural Science Foundation of China 62206165National Natural Science Foundation of China 62303295National Natural Science Foundation of China 62376150National Natural Science Foundation of China 81971641National Natural Science Foundation of China 82021002National Natural Science Foundation of China 82071200National Natural Science Foundation of China 82272039Science and Technology Innovation 2030-Major Projects 2022ZD021600the fellowship of China Postdoctoral Science Foundation 2022M722034
6 · The paper itself

Abstract

Tau pathology and its spatial propagation in Alzheimer's disease (AD) play crucial roles in the neurodegenerative cascade leading to dementia. However, the underlying mechanisms linking tau spreading to glucose metabolism remain elusive. To address this, we aimed to examine the association between pathologic tau aggregation, functional connectivity, and cascading glucose metabolism and further explore the underlying interplay mechanisms. In this prospective cohort study, we enrolled 79 participants with

Indexed as

Alzheimer DiseaseFluorodeoxyglucose F18Magnetic Resonance ImagingNerve NetPositron-Emission Tomographytau ProteinsAgedAged, 80 and overBrainConnectomeFemaleGlucoseHumansMaleMiddle AgedProspective StudiesFluorodeoxyglucose F18GlucoseMAPT protein, humantau ProteinsAlzheimer's diseasefunctional connectivityglucose metabolismPET imagingtau pathology

Identifiers

PMID38703095
PMCPMC11069321

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.