Evidence map›Paper›PMID 38703204›Full record

ArticleCellular and molecular life sciences : CMLS2024

Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl

Xueying Jin, Xueling Yue, Zhe Huang, Xiangkun Meng, Shengnan Xu, Yuna Wu, Ying Wan, Aiko Inoue, Megumi Narisawa, Lina Hu and 6 more

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Liraglutide Ameliorates Injury-Related Vascular Repair by Activating Autophagy Through Modulation of the PI3K-mTOR Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. CD8FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Increased Dipeptidyl Peptidase-4 Promotes Adipose Inflammation and Dysfunction in Mice Under Chronic Stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Article
  6. Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK-3β Signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Dexmedetomidine Reduces Chronic Stress-Related Thrombosis in a Mouse FeClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xueying JinDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China.
Xueling YueDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China. 1945199153@qq.com.
Zhe HuangDepartment of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Xiangkun MengDepartment of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Shengnan XuDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China.
Yuna WuDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China.
Ying WanDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China.
Aiko InoueDepartment of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Megumi NarisawaDepartment of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Lina HuDepartment of Public Health, Guilin Medical College, Guilin, 541199, Guangxi, People's Republic of China.
Guo-Ping ShiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Hiroyuki UmegakiDepartment of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Toyoaki MuroharaDepartment of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Yanna LeiDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China. leiyannalyn@126.com.
Masafumi KuzuyaDepartment of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Xian Wu ChengDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, 1327 Juzijie, Yanji, 133000, Jilin, People's Republic of China. chengxw0908@163.com.ORCID http://orcid.org/0000-0002-9758-0632

Funding

National Natural Science Foundation of China 81560240National Natural Science Foundation of China 81770485National Natural Science Foundation of China 82060099National Natural Science Foundation of China 82260087National Natural Science Foundation of China 82370424
6 · The paper itself

Abstract

backgroundExposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed cardiovascular tissues, and we investigated whether CTSK is involved in chronic stress-related thrombosis, focusing on stress serum-induced endothelial apoptosis. METHODS AND

resultsEight-week-old wild-type male mice (CTSK

conclusionsCTSK appeared to contribute to stress-related thrombosis in mice subjected to FeCl

Indexed as

ApoptosisCathepsin KChloridesDisease Models, AnimalFerric CompoundsThrombosisADAMTS13 ProteinAnimalsHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutPlasminogen Activator Inhibitor 1Stress, PsychologicalADAMTS13 ProteinCathepsin KChloridesCTSK protein, humanCtsk protein, mouseferric chlorideFerric CompoundsPlasminogen Activator Inhibitor 1Transcription Factor HES-1ApoptosisCathepsin KChronic stressEndothelial injuryThrombosis

Identifiers

PMID38703204
PMCPMC11069486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.