Evidence map›Paper›PMID 38704674›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation.

Yifan Zhang, Zixin Li, Houzuo Guo, Qibo Wang, Bowen Guo, Xi Jiang, Yishu Liu, Shengjie Cui, Zhengda Wu, Min Yu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yifan ZhangDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.ORCID 0000-0003-0701-3771
Zixin LiDepartment of Stomatology, Peking University People's Hospital, Beijing, 100044, PR China.
Houzuo GuoDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Qibo WangDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Bowen GuoCAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Xi JiangDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Yishu LiuDepartment of Stomatology, Beijing Chao-Yang Hospital of Capital Medical University, Beijing, 100020, China.
Shengjie CuiDepartment of General Dentistry, Laboratory of Biomimetic Nanomaterials, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Zhengda WuDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Min YuCentral Laboratory, Department of Orthodontics, National Center for Stomatology,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology,Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Lisha ZhuCentral Laboratory, Department of Orthodontics, National Center for Stomatology,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology,Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Liyuan ChenCentral Laboratory, Department of Orthodontics, National Center for Stomatology,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology,Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Ning DuCentral Laboratory, Department of Orthodontics, National Center for Stomatology,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology,Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Dan LuoCAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Ye LinDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Ping DiDepartment of Oral Implantology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology, Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Yan LiuCentral Laboratory, Department of Orthodontics, National Center for Stomatology,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology,Translational Research Center for Oro-craniofacial Stem Cells and Systemic Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.ORCID 0000-0002-8193-6729

Funding

Beijing International Science and Technology Cooperation Project Z221100002722003Beijing Natural Science Foundation L234017Innovative Research Team of High-level Local Universities in Shanghai SHSMU-ZLCX20212402Key R & D Plan of Ningxia Hui Autonomous Region 2020BCG01001Key Research Program of Central Health Commission 2022ZD18National Major Disease Multidisciplinary Collaborative Diagnosis and Treatment Capacity Building Project PKUSSNKP-202105National Natural Science Foundations of China 52372174National Natural Science Foundations of China 81771106National Natural Science Foundations of China 82230030Peking University Clinical Medicine Plus X - Young Scholars Project PKU2023LCXQ004Ten-Thousand Talents Program QNBJ2019-2
6 · The paper itself

Abstract

The regenerative treatment of infectious vertical bone defects remains difficult and challenging today. Current clinical treatments are limited in their ability to control bacteria and infection, which is unfavorable for new bone formation and calls for a new type of material with excellent osteogenic and antibacterial properties. Here a multifunctional scaffold is synthesized that mimics natural bone nanostructures by incorporating silver nanowires into a hierarchical, intrafibrillar mineralized collagen matrix (IMC/AgNWs), to achieve the therapeutic goals of inhibiting bacterial activity and promoting infectious alveolar bone augmentation in rats and beagle dogs. An appropriate concentration of 0.5 mg mL

Indexed as

Tissue ScaffoldsAnimalsAnti-Bacterial AgentsBiomimeticsBone RegenerationDisease Models, AnimalDogsMaleOsteogenesisPorphyromonas gingivalisRatsRats, Sprague-DawleyStreptococcus mutansAnti-Bacterial Agentsantibacterialmineralized collagenosseointegrationsilver nanowiresvertical bone augmentation

Identifiers

PMID38704674
PMCPMC11234421

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.