Evidence mapPaperPMID 38706364Full record

ReviewCurrent medicinal chemistry2025

Resveratrol in the Treatment of Gynecological Cancer: Mechanisms and Therapeutic Potential.

Mohammad Javad Mozafaryan, Pouria Rezaei, Fardin Masoudpoor, Amirmohammad Bahri, Mohammad Samini, Tahereh Farkhondeh, Mohammad Hossein Pourhanifeh, Saeed Samarghandian

Abstract readReview
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In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Javad MozafaryanDepartment of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran.
Pouria RezaeiDepartment of Physiology, Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran.
Fardin MasoudpoorDepartment of Basic Medical Sciences, Bushehr University of Medical Sciences, Bushehr, Iran.
Amirmohammad BahriDepartment of Basic Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
Mohammad SaminiDepartment of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Tahereh FarkhondehDepartment of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
Mohammad Hossein PourhanifehResearch hub institute, Tehran, Iran.
Saeed SamarghandianDepartment of Medical Physiology, Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gynecological cancers, encompassing endometrial, ovarian, and cervical cancer, pose significant challenges in clinical practice, often marked by high mortality rates and treatment resistance. Despite advances in standard therapies, including chemoradiation and surgery, tumor recurrence and metastasis remain formidable obstacles. In this context, there is a pressing need to explore novel therapeutic strategies that offer improved efficacy and reduced side effects. Herbal medicine, particularly compounds like resveratrol, has garnered attention for its diverse biological properties, including anticancer effects. Resveratrol, a multipotential nutraceutical, holds promise in gynecological cancer therapy through its modulation of key cellular and molecular processes. This review aims to provide an overview of the current status, challenges, and opportunities in utilizing resveratrol for gynecological cancer treatment. We discuss its role in miRNA regulation, clinical trial findings, and the development of effective formulations. By elucidating the underlying mechanisms of resveratrol's anticancer effects and exploring innovative delivery systems, we aim to shed light on the potential avenues for optimizing its therapeutic benefits in gynecological cancers.

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicGenital Neoplasms, FemaleResveratrolAnimalsFemaleHumansMicroRNAsAntineoplastic AgentsAntineoplastic Agents, PhytogenicMicroRNAsResveratrolapoptosis.breast cancercervical cancerendometrial cancergynecological cancerovarian cancerResveratrol

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.