Evidence mapPaperPMID 38706754Full record

ArticleFASEB bioAdvances2024

Cardiac lipotoxicity and fibrosis underlie impaired contractility in a mouse model of metabolic dysfunction-associated steatotic liver disease.

Olufunto O Badmus, Alexandre A da Silva, Xuan Li, Lucy C Taylor, Jennifer R Greer, Andrew R Wasson, Karis E McGowan, Parth R Patel, David E Stec

Abstract read
In one paragraph

Article in FASEB bioAdvances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Olufunto O BadmusDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.ORCID https://orcid.org/0000-0002-1020-2170
Alexandre A da SilvaDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.ORCID https://orcid.org/0000-0003-4504-0607
Xuan LiDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Lucy C TaylorDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.ORCID https://orcid.org/0009-0009-9267-6713
Jennifer R GreerDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Andrew R WassonDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Karis E McGowanDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Parth R PatelDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.
David E StecDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson Mississippi USA.ORCID https://orcid.org/0000-0001-8359-4008

Funding

Pilot Projects ProgramP30GM149404 · UNIVERSITY OF MISSISSIPPI MED CTR · 2025 to 2025
$1.2M
Cardiac protective mechanisms of melanocortin system activationR01HL163076 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 to 2025
$1.2M
NHLBI NIH HHS R01 HL163076NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM149404
6 · The paper itself

Abstract

The leading cause of death among patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is cardiovascular disease. A significant percentage of MASLD patients develop heart failure driven by functional and structural alterations in the heart. Previously, we observed cardiac dysfunction in hepatocyte-specific peroxisome proliferator-activated receptor alpha knockout (

Indexed as

cardiac apoptosiscardiac fibrosiscardiac lipid accumulationcardiomyocyte contractilityheart failurehepatic steatosispoor exercise tolerance

Identifiers

PMID38706754
PMCPMC11069051

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.