Evidence map›Paper›PMID 38707706›Full record

ArticleBrain communications2024

Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping.

Stavros Skouras, Maria-Lisa Kleinert, Edwin H M Lee, Christy L M Hui, Yi Nam Suen, Jazmin Camchong, Catherine S Y Chong, Wing Chung Chang, Sherry K W Chan, William T L Lo and 2 more

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stavros SkourasDepartment of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.ORCID https://orcid.org/0000-0003-2288-7821
Maria-Lisa KleinertFaculty of Medicine, University of Barcelona, 08036 Barcelona, Spain.
Edwin H M LeeDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0002-8909-0676
Christy L M HuiDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.
Yi Nam SuenDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0003-2766-8476
Jazmin CamchongDepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA.ORCID https://orcid.org/0000-0001-8658-5780
Catherine S Y ChongDepartment of Psychiatry, Kwai Chung Hospital, Hong Kong, China.
Wing Chung ChangDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.
Sherry K W ChanDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.
William T L LoDepartment of Psychiatry, Kwai Chung Hospital, Hong Kong, China.
Kelvin O LimDepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA.
Eric Y H ChenDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional connectivity resting-state functional magnetic resonance imaging has been proposed to predict antipsychotic treatment response in schizophrenia. However, only a few prospective studies have examined baseline resting-state functional magnetic resonance imaging data in drug-naïve first-episode schizophrenia patients with regard to subsequent treatment response. Data-driven approaches to conceptualize and measure functional connectivity patterns vary broadly, and model-free, voxel-wise, whole-brain analysis techniques are scarce. Here, we apply such a method, called connectivity concordance mapping to resting-state functional magnetic resonance imaging data acquired from an Asian sample (

Indexed as

connectivity concordance mappingfMRIresting-stateschizophreniatreatment resistant

Identifiers

PMID38707706
PMCPMC11069118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.