Evidence map›Paper›PMID 38707766›Full record

ArticleBioMed research international2024

Association between Interleukin-6 Gene Polymorphism (

Christian Obirikorang, Sylvester Yao Lokpo, William K B A Owiredu, Linda Ahenkorah-Fondjo, James Osei-Yeboah, Kwabena Obeng Duedu, Esther Ngozi Adejumo, Samuel Ametepe, Evans Adu Asamoah, Shadrack Asiedu Coffie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Relationship Between the Occurrence of Depression andInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christian ObirikorangDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0002-6128-1358
Sylvester Yao LokpoDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0002-1628-0735
William K B A OwireduDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Linda Ahenkorah-FondjoDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0003-0252-3190
James Osei-YeboahDepartment of Global and International Health, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0001-7982-5707
Kwabena Obeng DueduDepartment of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.ORCID https://orcid.org/0000-0001-5816-5172
Esther Ngozi AdejumoDepartment of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
Samuel AmetepeFaculty of Allied Health Sciences, Koforidua Technical University, Koforidua, Greater Eastern Region, Ghana.
Evans Adu AsamoahKumasi Centre for Collaborative Research, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0001-6374-0979
Shadrack Asiedu CoffieBiotechnology Laboratory, University of Ghana, Legon, Ghana.
Emmanuel Nattah MawuliDepartment of Molecular Diagnostics, Claron Health International, Accra, Ghana.ORCID https://orcid.org/0000-0002-1598-5442
Priscilla EssandohDepartment of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.ORCID https://orcid.org/0000-0002-2543-0395
Precious Kwablah KwadzokpuiLaboratory Department, Ho Teaching Hospital, Ho, Ghana.ORCID https://orcid.org/0000-0001-5044-7773

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is no conclusive evidence on the association between interleukin- (IL-) 6 gene polymorphism and type 2 diabetes mellitus (type 2 DM). Thus, this study is aimed at evaluating the role of Materials and Methods: We recruited into this hospital-based case-control study 174 patients with type 2 DM (75 DM alone and 99 with DM+HTN) and 149 healthy individuals between 2018 and 2020. Demographic, lifestyle, clinical, anthropometric, and haemodynamic variables were obtained. Fasting blood samples were collected for haematological, biochemical, and molecular analyses. Genomic DNA was extracted, amplified using Tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) technique, and genotyped for IL-6 gene polymorphism. Logistic regression analyses were performed to assess the association between IL-6 gene polymorphism and type 2 DM. Results: The minor allele frequency (MAF) of the Conclusion: The GC genotype and mutant C allele are risk genetic variants associated with type 2 DM in the Ghanaian population. The rs1800796 GC variant, dietary sugar intake, and exercise status appear to contribute significantly to the variations in circulating IL-6 levels but with weak effect sizes.

Indexed as

Diabetes Mellitus, Type 2Gene FrequencyGenetic Predisposition to DiseaseInterleukin-6Polymorphism, Single NucleotideAdultAgedAllelesCase-Control StudiesFemaleGenotypeGhanaHumansMaleMiddle AgedIL6 protein, humanInterleukin-6

Identifiers

PMID38707766
PMCPMC11068456

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.