Evidence map›Paper›PMID 38709403›Full record

ArticleMikrochimica acta2024

Electrochemical cytosensor utilizing tetrahedral DNA/bimetallic AuPd holothurian-shaped nanoparticles for ultrasensitive non-destructive detection of circulating tumor cells.

Hong Guo, Yang Fu, Siyu Chen, Yuxin Wei, Linzhi Xie, Mei Chen

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hong GuoClinical Laboratory, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Yang FuSchool of Bioscience and Technology, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Siyu ChenSchool of Bioscience and Technology, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Yuxin WeiSchool of Public Health, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Linzhi XieSchool of Public Health, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Mei ChenClinical Laboratory, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, Sichuan, China. 396762073@qq.com.

Funding

Graduate Inovation Foud of Chengdu Medical College YCX2023-01-42Innovative Research Group Project of the National Natural Science Foundation of China 82102516Sichuan Province Science and Technology Support Program 2023NSFSC0537
6 · The paper itself

Abstract

As a real-time fluid biopsy method, the detection of circulating tumor cells (CTCs) provides important information for the early diagnosis, precise treatment, and prognosis of cancer. However, the low density of CTCs in the peripheral blood hampers their capture and detection with high sensitivity and selectivity using currently available methods. Hence, we designed a sandwich-type electrochemical aptasensor that utilizes holothurian-shaped AuPd nanoparticles (AuPd HSs), tetrahedral DNA nanostructures (TDNs), and CuPdPt nanowire networks (NWs) interwoven with a graphdiyne (GDY) sheet for ultrasensitive non-destructive detection of MCF-7 breast cancer cells. CuPdPt NW-GDY effectively enhanced the electron transfer rate and coupled with the loaded TDNs. The TDNs could capture MCF-7 cells with precision and firmness, and the resulting composite complex was combined with AuPd HSs to form a sandwich-type structure. This novel aptasensor showed a linear range between 10 and 10

Indexed as

Aptamers, NucleotideBiosensing TechniquesDNAElectrochemical TechniquesGoldLimit of DetectionMetal NanoparticlesNeoplastic Cells, CirculatingPalladiumHumansMCF-7 CellsAptamers, NucleotideDNAGoldPalladiumAptamerCytosensorDifferential pulse voltammetryHolothurian-shaped nanoparticlesMCF-7 cellModified glassy carbon electrodeTetrahedral DNA

Identifiers

PMID38709403

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.