Evidence map›Paper›PMID 38710200›Full record

ArticleCancer science2024

CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma.

Mai Mochizuki, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Shungo Adachi, Haruna Fujimori, Akira Nakazato, Keitaro Fujii, Shinkichi Morita, Satoshi Saijoh, Tomoko Yamazaki and 7 more

Abstract read
In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. ERCC1/NGFR affects prognosis in basal-like breast cancer.European journal of medical research · 2025
    Article
  4. NJournal of bioenergetics and biomembranes · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mai MochizukiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID https://orcid.org/0000-0002-4649-0258
Rie Shibuya-TakahashiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Shin-Ichiro KannoIDAC Fellow Research Group for DNA Repair and Dynamic Proteome Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.
Shungo AdachiMolecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
Haruna FujimoriDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID https://orcid.org/0009-0008-8855-1216
Akira NakazatoDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Keitaro FujiiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Shinkichi MoritaDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Satoshi SaijohDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Tomoko YamazakiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Takayuki ImaiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Yukinori AsadaDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.
Kazunori YamaguchiMolecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Jun YasudaMolecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Norihisa ShindoCancer Chromosome Biology Unit, Miyagi Cancer Center Research Institute, Natori, Japan.
Kazuo SugamuraMolecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Keiichi TamaiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID https://orcid.org/0000-0003-0813-5885

Funding

Core Research for Evolutional Science and Technology JPMJCR20E6Japan Agency for Medical Research and Development 22nk0101583h0001Japan Society for the Promotion of Science 19K08430Japan Society for the Promotion of Science 20K09701Japan Society for the Promotion of Science 21H02396Japan Society for the Promotion of Science 21K07137Japan Society for the Promotion of Science 21K07186Japan Society for the Promotion of Science 21K07973Japan Society for the Promotion of Science 22H02225Japan Society for the Promotion of Science 22K07974Japan Society for the Promotion of Science 22K08085Japan Society for the Promotion of Science 22K09678Japan Society for the Promotion of Science 22K09696Kobayashi Foundation for Cancer ResearchTakeda Medical Research Foundation
6 · The paper itself

Abstract

RNAs, such as noncoding RNA, microRNA, and recently mRNA, have been recognized as signal transduction molecules. CD271, also known as nerve growth factor receptor, has a critical role in cancer, although the precise mechanism is still unclear. Here, we show that CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. We established CD271

Indexed as

Head and Neck NeoplasmsHeterogeneous-Nuclear Ribonucleoprotein Group A-BMouth NeoplasmsNerve Tissue ProteinsReceptors, Nerve Growth FactorRNA, MessengerSquamous Cell Carcinoma of Head and Neck3' Untranslated RegionsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleNeoplastic Stem Cells3' Untranslated RegionsHeterogeneous-Nuclear Ribonucleoprotein Group A-BhnRNP A2Nerve Tissue ProteinsNGFR protein, humanReceptors, Nerve Growth FactorRNA, MessengerCD271head and neck squamous cell carcinomahnRNPA2B1mRNAoral squamous cell carcinoma

Identifiers

PMID38710200
PMCPMC11247604

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.