ReviewNeuroscience and biobehavioral reviews2024
Allostasis, health, and development in Latin America.
Review in Neuroscience and biobehavioral reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Value drivers and barriers to the adoption of Precision Psychiatry in Latin America: a qualitative study.BMC psychiatry · 2026Article
- Childhood adversities and the exposome in dementia risk and brain health.Current opinion in psychiatry · 2026Review
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- From Early Adversity to Neurodegeneration: Stress Biomarkers as Predictive Signals for Lifespan Brain Health.International journal of molecular sciences · 2025Review
- Social exposome and brain health outcomes of dementia across Latin America.Nature communications · 2025Article
- Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.NeuroImage · 2025Article
- Resilience and brain health in global populations.Nature medicine · 2025Review
- Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas.Nature aging · 2025Article
- Chronic pain in the Chilean population: risk factors prevalence and cognitive associations.Frontiers in aging · 2025Article
- Global, regional and national burden of traumatic amputations from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021.Frontiers in public health · 2025Article
- Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.Nature medicine · 2024Article
- Educational disparities in brain health and dementia across Latin America and the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Brain clocks capture diversity and disparity in aging and dementia.Research square · 2024Article
- Development and validation of the Environmental Confinement Stressors Scale (ECSS-20).Frontiers in psychology · 2024Article
- Multilevel Impact of Parental Burnout on Mothers and Preschool Children.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
The lifespan is influenced by adverse childhood experiences that create predispositions to poor health outcomes. Here we propose an allostatic framework of childhood experiences and their impact on health across the lifespan, focusing on Latin American and Caribbean countries. This region is marked by significant social and health inequalities nested in environmental and social stressors, such as exposure to pollution, violence, and nutritional deficiencies, which critically influence current and later-life health outcomes. We review several manifestations across cognition, behavior, and the body, observed at the psychological (e.g., cognitive, socioemotional, and behavioral dysfunctions), brain (e.g., alteration of the development, structure, and function of the brain), and physiological levels (e.g., dysregulation of the body systems and damage to organs). To address the complexity of the interactions between environmental and health-related factors, we present an allostatic framework regarding the cumulative burden of environmental stressors on physiological systems (e.g., cardiovascular, metabolic, immune, and neuroendocrine) related to health across the life course. Lastly, we explore the relevance of this allostatic integrative approach in informing regional interventions and public policy recommendations. We also propose a research agenda, potentially providing detailed profiling and personalized care by assessing the social and environmental conditions. This framework could facilitate the delivery of evidence-based interventions and informed childhood-centered policy-making.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.