ArticleObesity (Silver Spring, Md.)2024
Smaller subcortical volume relates to greater weight gain in girls with initially healthy weight.
Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Early-Life Cumulative Intake of Ultra-Processed Foods and Subcortical Brain Volume at Age Six Years: A Prospective Cohort Study.The American journal of clinical nutrition · 2026Article
- Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.Developmental cognitive neuroscience · 2026Review
- Distinct Patterns of Weight Gain, Age, and Subcortical Microstructure in Early Adolescence.JAMA network open · 2025Observational
- Smaller Subcortical Volume in Reward Processing Regions Precedes Weight Gain in Youth With High Financial Adversity: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Sex-specific Effects of Outdoor Air Pollution on Subcortical Microstructure and Weight Gain: Findings from the ABCD StudybioRxiv : the preprint server for biology · 2025Article
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7 authors.
Funding
Abstract
objectiveAmong 3614 youth who were 9 to 12 years old and initially did not have overweight or obesity (12% [n = 385] developed overweight or obesity), we examined the natural progression of weight gain and brain structure development during a 2-year period with a high risk for obesity (e.g., pre- and early adolescence) to determine the following: 1) whether variation in maturational trajectories of the brain regions contributes to weight gain; and/or 2) whether weight gain contributes to altered brain development.
methodsData were gathered from the Adolescent Brain Cognitive Development (ABCD) Study. Linear mixed-effects regression models controlled for puberty, caregiver education, handedness, and intracranial volume (random effects: magnetic resonance scanner [MRI] scanner and participant). Because pubertal development occurs earlier in girls, analyses were stratified by sex.
resultsFor girls, but not boys, independent of puberty, greater increases in BMI were driven by smaller volumes over time in the bilateral accumbens, amygdala, hippocampus, and thalamus, right caudate and ventral diencephalon, and left pallidum (all p < 0.05).
conclusionsThe results suggest a potential phenotype for identifying obesity risk because underlying differences among regions involved in food intake were related to greater weight gain in girls, but not in boys. Importantly, 2 years of weight gain may not be sufficient to alter brain development, highlighting early puberty as a critical time to prevent negative neurological outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.