Evidence map›Paper›PMID 38711449›Full record

ArticleiScience2024

Deciphering the TET3 interactome in primary thymic developing T cells.

Dimitris Theofilatos, Tricia Ho, Greg Waitt, Tarmo Äijö, Lucio M Schiapparelli, Erik J Soderblom, Ageliki Tsagaratou

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. TET proteins regulateFrontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dimitris TheofilatosLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tricia HoDuke Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Greg WaittDuke Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Tarmo ÄijöLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lucio M SchiapparelliDepartment of Cell Biology, Duke University, Durham, NC, USA.
Erik J SoderblomDuke Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Ageliki TsagaratouLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Epigenetic Regulation of Lineage SpecificationR35GM138289 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSANGARATOU, AGELIKI · 2020 to 2024
$2.0M
Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass SpectrometerS10OD024999 · OD · DUKE UNIVERSITY · PI MOSELEY, MARTIN ARTHUR · 2018 to 2018
$600k
NIGMS NIH HHS R35 GM138289NIH HHS S10 OD024999
6 · The paper itself

Abstract

Ten-eleven translocation (TET) proteins are DNA dioxygenases that mediate active DNA demethylation. TET3 is the most highly expressed TET protein in thymic developing T cells. TET3, either independently or in cooperation with TET1 or TET2, has been implicated in T cell lineage specification by regulating DNA demethylation. However, TET-deficient mice exhibit complex phenotypes, suggesting that TET3 exerts multifaceted roles, potentially by interacting with other proteins. We performed liquid chromatography with tandem mass spectrometry in primary developing T cells to identify TET3 interacting partners in endogenous,

Indexed as

BiochemistryMolecular biologyMolecular interactionProteomics

Identifiers

PMID38711449
PMCPMC11070343

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.