Evidence map›Paper›PMID 38711928›Full record

ArticleFrontiers in cellular and infection microbiology2024

Genomic insights into the diversity, virulence, and antimicrobial resistance of group B

Maha Alzayer, Manal M Alkhulaifi, Ahmed Alyami, Mohammed Aldosary, Abdulaziz Alageel, Ghada Garaween, Atef Shibl, Arif M Al-Hamad, Michel Doumith

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
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  7. Deciphering the genetic context of the emerging OXA-484-producing carbapenem-resistant Escherichia coli from ST167 high-risk clone in the United Arab Emirates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  8. Novel Variant of New Delhi Metallo-Beta-Lactamase (Antibiotics (Basel, Switzerland) · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maha AlzayerDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Manal M AlkhulaifiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Ahmed AlyamiPathology and Clinical Laboratory, Medicine Administration, King Fahad Medical City, Riyadh, Saudi Arabia.
Mohammed AldosaryPathology and Clinical Laboratory, Medicine Administration, King Fahad Medical City, Riyadh, Saudi Arabia.
Abdulaziz AlageelPathology and Clinical Laboratory, Medicine Administration, King Fahad Medical City, Riyadh, Saudi Arabia.
Ghada GaraweenDepartment of Microbiology and Immunology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Atef ShiblDepartment of Microbiology and Immunology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Arif M Al-HamadDivision of Clinical Microbiology, Pathology and Laboratory Medicine, Qatif Central Hospital, Qatif, Saudi Arabia.
Michel DoumithInfectious Diseases Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Detailed assessment of the population structure of group B Methods: GBS isolates (n=89) were sequenced by Illumina and screened for virulence and antimicrobial resistance determinants. Genetic diversity was assessed by single nucleotide polymorphisms and core-genome MLST analyses. Results: Genome sequences revealed 28 sequence types (STs) and nine distinct serotypes, including uncommon serotypes VII and VIII. Majority of these STs (n=76) belonged to the human-associated clonal complexes (CCs) CC1 (33.71%), CC19 (25.84%), CC17 (11.24%), CC10/CC12 (7.87%), and CC452 (6.74%). Major CCs exhibited intra-lineage serotype diversity, except for the hypervirulent CC17, which exclusively expressed serotype III. Virulence profiling revealed that nearly all isolates (94.38%) carried at least one of the four alpha family protein genes (i.e., Discussion: These findings underscore the necessity for more rigorous characterization of GBS isolates causing infections.

Indexed as

Drug Resistance, BacterialGenetic VariationGenome, BacterialMultilocus Sequence TypingSerogroupStreptococcal InfectionsStreptococcus agalactiaeVirulence FactorsAdultAnti-Bacterial AgentsFemaleGenomicsGenotypeHumansMicrobial Sensitivity TestsPhylogenyAnti-Bacterial AgentsVirulence Factorsantimicrobial resistanceCC17group B streptococcusHvgAMLSTSaudi ArabiaST1212whole-genome sequencing

Identifiers

PMID38711928
PMCPMC11070470

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.