ArticlemedRxiv : the preprint server for health sciences2025
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
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210 authors.
Nora I StromDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-5261-8852
Zachary F GerringDepartment of Mental Health and Neuroscience, Translational Neurogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-2445-1266
Marco GalimbertiDepartment of Psychiatry, Human Genetics, Yale University, New Haven, CT, USA.ORCID 0000-0001-6052-156X
Dongmei YuDepartment of Center for Genomic Medicine, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7901-4365
Matthew W HalvorsenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-6707-2418
Abdel AbdellaouiDepartment of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1088-6784
Cristina Rodriguez-FontenlaCIMUS (Center for Research in Molecular Medicine and Chronic Diseases), Genomics and Bioinformatics, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.ORCID 0000-0002-9829-6393
Julia M SealockVanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-9346-3498
Tim BigdeliDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID 0000-0003-2215-5946
Jonathan R ColemanSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID 0000-0002-6759-0944
Behrang MahjaniDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6087-9537
Jackson G ThorpMental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-9461-6417
Katharina BeyDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-6392-4997
Christie L BurtonDepartment of Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-8955-6528
Jurjen J LuykxDepartment of Psychiatry, Brain, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-6439-2774
Gwyneth ZaiMolecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0002-0894-6867
Silvia AlemanyPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-7925-6767
Christine AndreObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Kathleen D AsklandDepartment of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-1467-8923
Julia BäckmannCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0003-3399-2838
Nerisa BanajLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0002-6317-8549
Cristina BarlassinaDepartment of Health Sciences, University of Milano, Milano, Italy.ORCID 0000-0001-7407-2697
Judith Becker NissenDepartment of Child and Adolescent Psychiatry, Aarhus University Hospital, Psychiatry, Aarhus, Denmark.ORCID 0000-0003-4063-6866
O Joseph BienvenuDepartment of Psychiatry and Behavioral Sciences, General Hospital Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8466-102X
Donald BlackDepartments of Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8038-1971
Michael H BlochDepartment of Child Study Center and Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0003-0352-4080
Sigrid BørteDepartment of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-9540-3256
Rosa BoschDepartment of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0002-7596-183X
Michael BreenDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6739-939X
Brian P BrennanObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.ORCID 0000-0001-5468-6552
Helena BrentaniDepartment of Psychiatry, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-5192-4682
Joseph D BuxbaumDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8898-8313
Jonas Bybjerg-GrauholmDepartment for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0003-1705-4008
Enda M ByrneChild Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-9491-7797
Judit Cabana-DominguezPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-4732-7284
Beatriz CamarenaPharmacogenetics Department, Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Mexico City, México.ORCID 0000-0001-7737-501X
Adrian CamarenaDepartment of Surgery, Duke University, Durham, NC, USA.ORCID 0000-0001-8512-0607
Carolina CappiDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.ORCID 0000-0001-6661-3756
Angel CarracedoCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), Genomics and Bioinformatics Group, University of Santiago de Compostela, Santiago de Compostela, Spain.ORCID 0000-0003-1085-8986
Miguel CasasPrograma MIND Escoles, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0003-3496-8522
Maria Cristina CavalliniDepartment of Psychiatry, Ospedale San Raffaele, Milano, Italy.ORCID 0000-0001-5913-1468
Valentina CiulloLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0002-4095-7806
Edwin H CookDepartment of Psychiatry, University of Illinois Chicago, Chicago, IL, USA.ORCID 0000-0002-5848-5114
Jesse CrosbyObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Bernadette A CullenDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA.ORCID 0000-0003-1762-092X
Elles J De SchipperCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0001-9494-451X
Richard DelormeChild and Adolesccent Psychiatry Department, APHP, Paris, France.ORCID 0000-0002-5614-3663
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-8140-8061
Jason A EliasPsychiatry, McLean Hospital OCDI, Harvard Medical School, Belmont, MA, USA.
Xavier EstivillqGenomics (Quantitative Genomics Laboratories), Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0002-0723-2256
Martha J FalkensteinObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.ORCID 0000-0001-5074-3409
Bengt T FundinDepartment of Medical Epidemiology and Biostatistics, Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6037-7331
Lauryn GarnerObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Christina GirondaObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Fernando S GoesDepartment of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6262-8264
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Child & Adolescent Psychiatry, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0178-1764
Jakob GroveDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-2284-5744
Wei GuoGenetic Epidemiology Research Branch, National Institute of Mental Health, Bethesda, MD, USA.ORCID 0000-0002-4322-3699
Jan HaavikDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0001-7865-2808
Kristen HagenDepartment of Psychiatry, Møre og Romsdal Hospital Trust, Molde, Norway.ORCID 0000-0002-4286-1277
Kelly HarringtonMillion Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.ORCID 0000-0001-9668-183X
Alexandra HavdahlPsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-9268-0423
Kira D HöfflerDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-0837-1469
Ana G HounieDepartment of Psychiatry, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-5026-2880
Donald HucksDepartment of Medicine, Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-2700-5798
Christina HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0327-2410
Magdalena JaneckaDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-7406-0776
Eric JenikeObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Elinor K KarlssonDepartment of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0002-4343-3776
Kara KelleyObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Julia KlawohnDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9436-6948
Janice E KrasnowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0316-6279
Kristi KrebsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-0494-2751
Christoph LangeDepartment of Biostatistics, T.H. Chan School of Public Health, Boston, MA, USA.
Nuria LanzagortaResearch Department, Grupo Medico Carracci, Mexico City, Mexico.ORCID 0000-0001-6769-6813
Daniel LeveyDepartment of Psychiatry, Yale University, West Haven, CT, USA.ORCID 0000-0001-8431-9569
Kerstin Lindblad-TohDepartment of Vertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8338-0253
Fabio MacciardiDepartment of Psychiatry, University of California, Irvine (UCI), Irvine, CA, USA.ORCID 0000-0003-0537-4266
Brion MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-9809-0064
Brittany MathesObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Evonne McArthurVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4566-4321
Nathaniel McGregorCOBRE Center for Neuromodulation, Butler Hospital, Providence, RI, USA.ORCID 0000-0001-7195-4993
Nicole C McLaughlinDepartment of Psychiatry & Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA.ORCID 0000-0002-4016-2747
Sandra MeierDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-3287-5894
Euripedes C MiguelDepartment of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-9393-3103
Maureen MulhernDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-8642-4741
Paul S NestadtDepartment of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA.
Erika L NurmiDepartment of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4893-8957
Kevin S O'ConnellDepartment of Clinical Medicine, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-6865-8795
Lisa OsieckiDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-9408-8722
Olga Therese OusdalDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-0728-3141
Teemu PalviainenInstitute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7847-8384
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8057-3543
Fabrizio PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0003-3566-5494
Federica PirasDepartment of Clinical Neuroscience and Neurorehabilitation, Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0002-9546-7038
Sriramya PotluriObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.ORCID 0000-0003-3877-0038
Raquel RabionetDepartment of Genetics, Microbiology and Statistics, IBUB, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0001-5006-8140
Alfredo RamirezDepartment of Psychiatry and Psychotherapy, Division of Neurogenetics and Molecular Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-4991-763X
Scott RauchDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.ORCID 0000-0001-7699-6754
Abraham ReichenbergDepartment of Mental Disorders, Norwegian Institute of Public Health, New York, NY, USA.ORCID 0000-0003-2729-8575
Mark A RiddleDepartment of Psychiatry and Behavioral Sciences, Child and Adolescent, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8764-2134
Stephan RipkeDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.ORCID 0000-0003-3622-835X
Maria C RosárioDepartment of Psychiatry, Child and Adolescent Psychiatry Unit (UPIA), Federal University of São Paulo (UNIFESP), São Paulo, Brazil.ORCID 0000-0002-8577-3306
Aline S SampaioDepartment of Neurosciences and Mental Health, Medical School, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0001-5568-6167
Miriam A SchieleDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, University of Freiburg, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2613-6515
Anne Heidi SkogholtDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Trondheim, Norway.ORCID 0000-0001-7466-0405
Laura G SloofmanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7628-4378
Jan SmitDepartment of Psychiatry, Faculty of Medicine, Locaion Vumc, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-6070-4865
María Soler ArtigasPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-3213-1107
Laurent F ThomasDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-0548-2486
Eric TifftObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.ORCID 0000-0002-7480-0276
Homero ValladaDepartment of Psychiatry, Universidade de Sao Paulo, São Paulo, Brazil.ORCID 0000-0001-5123-8295
Nathanial van KirkOCD Institute, Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.ORCID 0000-0002-1975-4238
Jeremy Veenstra-VanderWeeleDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, Columbia University, New York, NY, USA.ORCID 0000-0002-6349-1076
Nienke N VulinkDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-8991-9627
Christopher P WalkerHuman Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-6069-0184
Ying WangDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jens R WendlandLaboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD, USA.ORCID 0000-0001-5106-5013
Bendik S WinsvoldDepartment of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-4171-8919
Yin YaoDepartment of Computional Biology, Institute of Life Science, Fudan University, Fudan, China.ORCID 0000-0001-7487-4294
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7694-6391
Estonian Biobank
23andMe Inc.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-0313-793X
Pino AlonsoDepartment of Psychiatry, OCD Clinical and Research Unit, Bellvitge Hospital, Barcelona, Spain.ORCID 0000-0002-5779-9111
Götz BerberichPsychosomatic Department, Windach Hospital of Neurobehavioural Research and Therapy, Windach, Germany.ORCID 0000-0001-8300-9294
Kathleen K BucholzDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3794-0736
Cynthia M BulikDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7772-3264
Danielle CathDepartments of Rijksuniversiteit Groningen and Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-9539-4118
Damiaan DenysDepartment of Psychiatry, Institute of The Royal Netherlands Academy of Arts and Sciences (NIN-KNAW), Amsterdam, The Netherlands.ORCID 0000-0002-3191-3844
Valsamma EapenDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW, Sydney, New South Wales, Australia.ORCID 0000-0001-6296-8306
Howard EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-0344-9690
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany.ORCID 0000-0003-2873-8667
Thomas V FernandezChild Study Center and Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0830-022X
Abby J FyerDepartment of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.ORCID 0000-0002-0944-2505
J M GazianoDepartment of Medicine, VA Boston Healthcare System, Boston, MA, USA.ORCID 0000-0002-5384-9767
Dan A GellerDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8692-4156
Hans J GrabeDepartment of Psychiatry & Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0003-3684-4208
Benjamin D GreenbergCOBRE Center on Neuromodulation, Butler Hospital, Providence, RI, USA.ORCID 0000-0002-5648-0002
Gregory L HannaDepartment of Psychiatry, Child and Adolescent Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0742-6990
Ian B HickieBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-8832-9895
David M HougaardDepartment for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-5928-3517
Norbert KathmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-1348-7060
James KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8733-3806
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0001-7803-580X
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4496-6451
Stéphanie Le HellardDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-8085-051X
Marion LeboyerDepartment of Addictology and Psychiatry, Univ Paris Est Créteil, AP-HP, Inserm, Paris, France.ORCID 0000-0001-5473-3697
Christine LochnerDepartment of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Stellenbosch, South Africa.ORCID 0000-0002-4766-3704
James T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0370-0777
Sarah E MedlandDepartment of Mental Health, Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-1382-380X
Preben B MortensenCenter for Genomics and Personalized Medicine, Aarhus, Denmark.ORCID 0000-0002-4782-1450
Benjamin M NealeAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1513-6077
Humberto NicoliniDepartment of Psychiatry, Psychiatry, Carracci Medical Group, Mexico City, México.ORCID 0000-0003-2494-0067
Merete NordentoftMental Health Center Copenhagen, Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.ORCID 0000-0003-4895-7023
Michele PatoDepartment of Psychiatry, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-4589-7398
Carlos PatoDepartment of Psychiatry, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-5858-266X
David L PaulsDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8107-345X
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.ORCID 0000-0003-4195-7194
Christopher PittengerDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0003-2117-9321
Danielle PosthumaDepartment of Complex Trait Genetics, Vrije Universiteit Amsterdam, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0001-7582-2365
Josep Antoni Ramos-QuirogaDepartment of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID 0000-0003-1622-0350
Steven A RasmussenDepartment of Psychiatry & Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA.ORCID 0000-0002-8327-0692
Margaret A RichterDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5450-2936
David R RosenbergDepartment of Psychiatry and Behavioral Neurosciences, Child and Adolescent Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA.ORCID 0000-0002-0005-4151
Stephan RuhrmannDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.ORCID 0000-0002-6022-2364
Jack F SamuelsDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6715-7905
Sven SandinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6994-4884
Paul SandorDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-2397-0758
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0002-7432-4249
Dan J SteinDepartment of Psychiatry & Neuroscience Institute, SAMRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, Western Cape, South Africa.ORCID 0000-0001-7218-7810
S Evelyn StewartDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-0994-6383
Eric A StorchDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-7631-3703
Barbara E StrangerDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-9021-7331
Maurizio TurielDepartment of Cardiology, University of Milan, Milan, Italy.ORCID 0000-0002-8793-2112
Thomas WergeInstitute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services (RHP), Copenhagen, Denmark.ORCID 0000-0003-1829-0766
Ole A AndreassenInstitute of Clinical Medicine, NORMENT Centre, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Anders D BørglumDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-8627-7219
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), University of Zurich, Zürich, Switzerland.ORCID 0000-0002-8161-8683
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0001-8157-9744
Bjarne K HansenBergen Center for Brain Plasticity (BCBP), Psychiatry, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0001-5659-1119
Christian RückCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0002-8742-0168
Nicholas G MartinDepartment of Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-4069-8020
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5323-3102
Ole MorsPsychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.ORCID 0000-0002-5660-0393
Ted Reichborn-KjennerudDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-4653-0034
Marta RibasésPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0003-1039-1116
Gerd KvaleDepartment of Mental Health, Norwegian University for Science and Technology, Trondheim, Norway.ORCID 0000-0001-5449-2344
David Mataix-ColsCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0002-4545-0924
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, University of Freiburg, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-2550-9132
Edna GrünblattNeuroscience Center Zurich, University of Zurich and the ETH Zuric, Zurich, Switzerland.ORCID 0000-0001-8505-7265
Michael WagnerDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.ORCID 0000-0003-2589-6440
John-Anker ZwartHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0001-5721-0154
Gerome BreenSocial, Genetic, and Developmental Psychiatric Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID 0000-0003-2053-1792
Gerald NestadtDepartment of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-9461-5249
Jaakko KaprioInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Paul D ArnoldDepartment of Psychiatry, The Mathison Centre for Mental Health Research & Education, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-2496-4624
Dorothy E GriceDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8833-2549
James A KnowlesDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-3307-5741
Helga AskPsychGen Center for Genetic Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-0149-5319
Karin J VerweijDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9868-7821
Lea K DavisDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5143-2282
Dirk J SmitDepartment of Psychiatry, Amsterdam UMC location AMC, Amsterdam, The Netherlands.ORCID 0000-0001-8301-8860
James J CrowleyCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0001-9051-1557
Jeremiah M ScharfDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-4742-5896
Murray B SteinPsychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.ORCID 0000-0001-9564-2871
Joel GelernterDepartment of Psychiatry, Human Genetics (Psychiatry), Yale University School of Medicine, West Haven, CT, USA.ORCID 0000-0002-4067-1859
Carol A MathewsPsychiatry and Genetics Institute, Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-2208-7058
Eske M DerksDepartment of Mental Health and Neuroscience, QIMR Berghofer, Brisbane, Queensland, Australia.ORCID 0000-0002-6292-6883
Manuel MattheisenDepartment of Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians University Munich, Munich, Germany.ORCID 0000-0002-8442-493X
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MVanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MProject 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, JOSEPH HYUNGWOO · 2020 to 2025
$103.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MUCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0MMultimodal Investigation of Excitatory/Inhibitory Imbalances and Network Dysfunction Related to Motor Control in OCD Youth: ùH fMRS and fMRI ApplicationsR01MH059299 · NIMH · WAYNE STATE UNIVERSITY · PI DIWADKAR, VAIBHAV A., ROSENBERG, DAVID R · 1999 to 2025
$11.1MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MIntegrating Common and Rare Variation to Discover Genes Associated with Tourette SyndromeR01NS102371 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATHEWS, CAROL A, OPHOFF, ROEL A · 2018 to 2022
$7.4MBLRD VA I01 BX006482BLRD VA IK2 BX005058CSRD VA I01 CX001849HSRD VA IP1 HX002375NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS U19 HL065962NIAAA NIH HHS R01 AA026364NIAAA NIH HHS U10 AA008401NIA NIH HHS R56 AG068026NIA NIH HHS U19 AG068054NICHD NIH HHS R01 HD074711NIDA NIH HHS R01 DA054869NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIGMS NIH HHS T32 GM008042NIGMS NIH HHS T32 GM080178NIMH NIH HHS K23 MH066284NIMH NIH HHS K99 MH128540NIMH NIH HHS R01 MH050214NIMH NIH HHS R01 MH058376NIMH NIH HHS R01 MH059299NIMH NIH HHS R01 MH071507NIMH NIH HHS R01 MH079487NIMH NIH HHS R01 MH079488NIMH NIH HHS R01 MH079489NIMH NIH HHS R01 MH079494NIMH NIH HHS R01 MH085321NIMH NIH HHS R01 MH093381NIMH NIH HHS R01 MH101493NIMH NIH HHS R01 MH103657NIMH NIH HHS R01 MH105500NIMH NIH HHS R01 MH110427NIMH NIH HHS R01 MH113362NIMH NIH HHS R01 MH114927NIMH NIH HHS R01 MH124679NIMH NIH HHS R01 MH124851NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH124873NIMH NIH HHS R21 MH109938NIMH NIH HHS R56 MH120736NINDS NIH HHS R01 NS032830NINDS NIH HHS R01 NS102371NINDS NIH HHS R01 NS105746
Abstract
Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.