Evidence map›Paper›PMID 38712264›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Pace of Aging in older adults matters for healthspan and lifespan.

A Balachandran, H Pei, Y Shi, J Beard, A Caspi, A Cohen, B W Domingue, C Eckstein Indik, L Ferrucci, A Furuya and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

A BalachandranRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID 0000-0001-6856-7140
H PeiRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
Y ShiRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
J BeardRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
A CaspiDepartment of Psychology & Neuroscience, Duke University, Durham, NC, USA.
A CohenRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
B W DomingueGraduate School of Education, Stanford University, Palo Alto, CA, USA.
C Eckstein IndikRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
L FerrucciNational Institute on Aging, Bethesda, MD, USA.
A FuruyaRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
M KothariRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
T E MoffittSocial, Genetic, and Developmental Psychiatry Unit, Institute of Psychiatry, Kings College, University of London, London, UK.
C RyanRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
V SkirbekkNorwegian Institute for Public Health, Oslo, Norway.
Y ZhangRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
D W BelskyRobert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID 0000-0001-5463-2212

Funding

Global HIV Implementation Science Research Training Grant RenewalT32AI114398 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Yael R Hirsch-Moverman · 2014 to 2026
$4.1M
Long-term multi-omics follow-up of the CALERIE Trial to generate new knowledge for geroscienceR01AG061378 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Daniel Walker Belsky · 2019 to 2026
$2.9M
NIAID NIH HHS T32 AI114398NIA NIH HHS R01 AG061378
6 · The paper itself

Abstract

As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy analysis do not distinguish differences caused by early-life factors, such as prenatal care and nutrition, from those caused by ongoing changes in people's bodies due to aging. Here we introduce an adapted Pace of Aging method designed to quantify differences between individuals and populations in the speed of aging-related health declines. The adapted Pace of Aging method, implemented in data from the US Health and Retirement Study and English Longitudinal Study of Aging (N=21,463), integrates longitudinal data on blood biomarkers, physical measurements, and functional tests. It reveals stark differences in rates of aging between population subgroups and demonstrates strong and consistent prospective associations with incident morbidity, disability, and mortality. Pace of Aging can advance the population science of healthy longevity.

Identifiers

PMID38712264
PMCPMC11071564

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.