Evidence map›Paper›PMID 38712705›Full record

SynthesisEcology letters2024

Are novel or locally adapted pathogens more devastating and why? Resolving opposing hypotheses.

Erin L Sauer, Matthew D Venesky, Taegan A McMahon, Jeremy M Cohen, Scott Bessler, Laura A Brannelly, Forrest Brem, Allison Q Byrne, Neal Halstead, Oliver Hyman and 5 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Ecology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Erin L SauerDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA.ORCID https://orcid.org/0000-0002-8339-6498
Matthew D VeneskyDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.
Taegan A McMahonDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.
Jeremy M CohenDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.
Scott BesslerDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.
Laura A BrannellyEcology and Evolutionary Biology, Tulane University, New Orleans, Louisiana, USA.ORCID https://orcid.org/0000-0003-2975-9494
Forrest BremBiology Department, University of Memphis, Memphis, Tennessee, USA.
Allison Q ByrneDepartment of Environmental Science, Policy, and Management, University of California, Berkeley, California, USA.
Neal HalsteadDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.
Oliver HymanBiology Department, James Madison University, Harrisonburg, Virginia, USA.
Pieter T J JohnsonEcology and Evolutionary Biology, University of Colorado, Boulder, Colorado, USA.ORCID https://orcid.org/0000-0002-7997-5390
Corinne L Richards-ZawackiEcology and Evolutionary Biology, Tulane University, New Orleans, Louisiana, USA.
Samantha L RumschlagDepartment of Biology, Miami University, Oxford, Ohio, USA.
Brittany SearsDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.
Jason R RohrDepartment of Integrative Biology, University of South Florida, Tampa, Florida, USA.

Funding

Effects of agricultural expansion and intensification on infectionsR01TW010286 · FIC · UNIVERSITY OF SOUTH FLORIDA · PI REMAIS, JUSTIN V, ROHR, JASON ROBERT · 2015 to 2019
$2.4M
EID disease in complex communities: multi-host multi-pathogen interactionsR01GM109499 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BRIGGS, CHERYL J · 2013 to 2016
$1.7M
From specialist to generalist: biotic and abiotic reservoirs of fungal pathogensR01GM135935 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BRIGGS, CHERYL J · 2019 to 2022
$1.6M
Division of Environmental Biology 2017785Division of Environmental Biology 2109293Division of Integrative Organismal Systems 1754868FIC NIH HHS R01 TW010286Intramural EPA EPA999999NIGMS NIH HHS R01 GM109499NIGMS NIH HHS R01 GM135935
6 · The paper itself

Abstract

There is a rich literature highlighting that pathogens are generally better adapted to infect local than novel hosts, and a separate seemingly contradictory literature indicating that novel pathogens pose the greatest threat to biodiversity and public health. Here, using Batrachochytrium dendrobatidis, the fungus associated with worldwide amphibian declines, we test the hypothesis that there is enough variance in "novel" (quantified by geographic and phylogenetic distance) host-pathogen outcomes to pose substantial risk of pathogen introductions despite local adaptation being common. Our continental-scale common garden experiment and global-scale meta-analysis demonstrate that local amphibian-fungal interactions result in higher pathogen prevalence, pathogen growth, and host mortality, but novel interactions led to variable consequences with especially virulent host-pathogen combinations still occurring. Thus, while most pathogen introductions are benign, enough variance exists in novel host-pathogen outcomes that moving organisms around the planet greatly increases the chance of pathogen introductions causing profound harm.

Indexed as

BatrachochytriumHost-Pathogen InteractionsAdaptation, PhysiologicalAmphibiansAnimalsAnuraMycosesPhylogenychytridiomycosiscoevolutioninfectious diseaselocal adaptationnaïve host syndromepathogen pollution

Identifiers

PMID38712705
PMCPMC11441375

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.