Evidence map›Paper›PMID 38713307›Full record

ArticleJournal of neurovirology2024

Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4

Stephanie B H Gumbs, Arjen J Stam, Tania Mudrikova, Pauline J Schipper, Andy I M Hoepelman, Petra M van Ham, Anne L Borst, LMarije Hofstra, Lavina Gharu, Stephanie van Wyk and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stephanie B H Gumbs *Translational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Arjen J Stam *Translational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Tania MudrikovaDepartment of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Pauline J SchipperTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Andy I M HoepelmanDepartment of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Petra M van HamTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Anne L BorstTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
LMarije HofstraTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Lavina GharuTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.
Stephanie van WykCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
Eduan WilkinsonKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Lot D de WitteDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Annemarie M J WensingTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands. a.m.j.wensing@umcutrecht.nl.ORCID 0000-0003-3790-8891
Monique NijhuisTranslational Virology, Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.

Funding

Aidsfonds P-13204Aidsfonds P-37203
6 · The paper itself

Abstract

Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon disease progression, transmigrating CCR5-using T-cell tropic viruses are hypothesized to evolve into macrophage-tropic viruses in the CNS that can efficiently infect low CD4-expressing cells, such as microglia. We examined HIV-1 RNA concentration, co-receptor usage, and CSF compartmentalization in paired CSF and blood samples from 19 adults not on treatment. Full-length envelope CSF- and plasma-derived reporter viruses were generated from 3 subjects and phenotypically characterized in human primary CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsMicrogliaReceptors, CCR5RNA, ViralVirus ReplicationAdultCells, CulturedFemaleHumansMaleMiddle AgedReceptors, CXCR4Viral LoadViral TropismCCR5 protein, humanReceptors, CCR5Receptors, CXCR4RNA, ViralCompartmentalizationCSFHIVMicrogliaPlasma

Identifiers

PMID38713307
PMCPMC11512886

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.