ArticleScientific reports2024
Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women.JAMA network open · 2022Pooled it
- Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus.BMC genomics · 2026Article
- Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia.International journal of molecular sciences · 2026Article
- Endothelial Susceptibility-Related Genetic Variants and Hypertensive Disorders of Pregnancy-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Experiences of Discrimination and DNA Methylation Among Black Nulliparous Women.Journal of racial and ethnic health disparities · 2026Article
- Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum.JAMA cardiology · 2026Article
- Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Observational
- A polygenic growth score and risk for large for gestational age birth weight.Journal of the Endocrine Society · 2026Article
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Sex-specific placental transcriptome alterations in late-onset preeclampsia reveal male-biased immune and metabolic dysregulation.Biology of sex differences · 2025Observational
- Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study.medRxiv : the preprint server for health sciences · 2025Article
- Use of a Maternal Genetic Risk Score to Derive and Test a Genetically Customized Fetal Growth Curve.O&G open · 2025Article
- Identification of Sample Processing Errors in Microbiome Studies Using Host Genetic Profiles.bioRxiv : the preprint server for biology · 2025Article
- Maternal parity modifies the association of birthweight polygenic score with fetal growth.Scientific reports · 2025Article
- Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women.Journal of the American College of Cardiology · 2025Observational
- Deciphering the genetic interplay between depression and dysmenorrhea: a Mendelian randomization study.Briefings in bioinformatics · 2024Article
- Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b.Genetics · 2023Article
- Using Association Rules to Understand the Risk of Adverse Pregnancy Outcomes in a Diverse Population.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023Article
- Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause of morbidity and mortality worldwide. Yet the pathophysiology of APOs is poorly understood, limiting our ability to prevent and treat these conditions. To search for genetic markers of maternal risk for four APOs, we performed multi-ancestry genome-wide association studies (GWAS) for pregnancy loss, gestational length, gestational diabetes, and preeclampsia. We clustered participants by their genetic ancestry and focused our analyses on three sub-cohorts with the largest sample sizes: European, African, and Admixed American. Association tests were carried out separately for each sub-cohort and then meta-analyzed together. Two novel loci were significantly associated with an increased risk of pregnancy loss: a cluster of SNPs located downstream of the TRMU gene (top SNP: rs142795512), and the SNP rs62021480 near RGMA. In the GWAS of gestational length we identified two new variants, rs2550487 and rs58548906 near WFDC1 and AC005052.1, respectively. Lastly, three new loci were significantly associated with gestational diabetes (top SNPs: rs72956265, rs10890563, rs79596863), located on or near ZBTB20, GUCY1A2, and RPL7P20, respectively. Fourteen loci previously correlated with preterm birth, gestational diabetes, and preeclampsia were found to be associated with these outcomes as well.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.