Observational studyCardiovascular diabetology2024
Impact of acute glycemic variability on short-term outcomes in patients with ST-segment elevation myocardial infarction: a multicenter population-based study.
Observational study in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive value of different glycemic variability indicators for prognosis in critically ill patients: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- An Inverted U-shaped Relationship between Glycemic Variability and Mortality in Patients with Severe Pulmonary Embolism: A Retrospective Study.Journal of atherosclerosis and thrombosis · 2026Article
- Association between glycemic variability and mortality after coronary stent implantation in critically ill patients: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Cumulative stress hyperglycemia ratio exposure and dynamic trajectories reveal prognostic determinants of acute hyperlipidemic pancreatitis: an 5-year cohort study.Lipids in health and disease · 2026Article
- Association of early blood glucose metrics with short- and long-term prognosis in acute myocardial infarction patients: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Correlation of glycemic variability with the risk of atrial fibrillation and in-hospital mortality in patients diagnosed with obstructive sleep apnea: a retrospective study based on the Medical Information Mart for Intensive Care database.Journal of thoracic disease · 2026Article
- Simultaneous assessment of stress hyperglycemia ratio and glucose variability to predict all-cause mortality in sepsis patients across different glucose metabolic states: an observational cohort study with interpretable machine learning approach.International journal of surgery (London, England) · 2026Observational
- The additive effect of hemoglobin glycation index and glycemic variability to predict mortality in cardiac intensive care patients with and without diabetes.Scientific reports · 2025Article
- Combined assessment of stress hyperglycemia ratio and glycemic variability to predict all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases across different glucose metabolic states: an observational cohort study with machine learning.Cardiovascular diabetology · 2025Observational
- Glycemic Comparison Index (GCI): a retrospective analysis of its prognostic value in ICU patients with AMI and diabetes.BMC endocrine disorders · 2025Article
- Physiological-immune resilience risk assessment model for predicting adverse cardiac outcomes in patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- U-shaped association between the glycemic variability and prognosis in hemorrhagic stroke patients: a retrospective cohort study from the MIMIC-IV database.Frontiers in endocrinology · 2025Article
- The clinical importance of measuring glycaemic variability: Utilising new metrics to optimise glycaemic control.Diabetes, obesity & metabolism · 2024Review
- Predictive value of glucose coefficient of variation for in-hospital mortality in acute myocardial infarction patients undergoing PCI: Insights from the MIMIC-IV database.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundGiven the increasing attention to glycemic variability (GV) and its potential implications for cardiovascular outcomes. This study aimed to explore the impact of acute GV on short-term outcomes in Chinese patients with ST-segment elevation myocardial infarction (STEMI).
methodsThis study enrolled 7510 consecutive patients diagnosed with acute STEMI from 274 centers in China. GV was assessed using the coefficient of variation of blood glucose levels. Patients were categorized into three groups according to GV tertiles (GV1, GV2, and GV3). The primary outcome was 30-day all-cause death, and the secondary outcome was major adverse cardiovascular events (MACEs). Cox regression analyses were conducted to determine the independent correlation between GV and the outcomes.
resultsA total of 7136 patients with STEMI were included. During 30-days follow-up, there was a significant increase in the incidence of all-cause death and MACEs with higher GV tertiles. The 30-days mortality rates were 7.4% for GV1, 8.7% for GV2 and 9.4% for GV3 (p = 0.004), while the MACEs incidence rates was 11.3%, 13.8% and 15.8% for the GV1, GV2 and GV3 groups respectively (p < 0.001). High GV levels during hospitalization were significantly associated with an increased risk of 30-day all-cause mortality and MACEs. When analyzed as a continuous variable, GV was independently associated with a higher risk of all-cause mortality (hazard ratio [HR] 1.679, 95% confidence Interval [CI] 1.005-2.804) and MACEs (HR 2.064, 95% CI 1.386-3.074). Additionally, when analyzed as categorical variables, the GV3 group was found to predict an increased risk of MACEs, irrespective of the presence of diabetes mellitus (DM).
conclusionOur study findings indicate that a high GV during hospitalization was significantly associated with an increased risk of 30-day all-cause mortality and MACE in Chinese patients with STEMI. Moreover, acute GV emerged as an independent predictor of increased MACEs risk, regardless of DM status.
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