Evidence map›Paper›PMID 38715114›Full record

ArticleImmunity & ageing : I & A2024

Increased levels of GM-CSF and CXCL10 and low CD8

Johanne Poisson, Carine El-Sissy, Arnaud Serret-Larmande, Nikaïa Smith, Morgane Lebraud, Jean-Loup Augy, Catherine Conti, Cécile Gonnin, Benjamin Planquette, Jean-Benoît Arlet and 22 more

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In one paragraph

Article in Immunity & ageing : I & A, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Johanne Poisson *Université Paris Cité, Paris, France.
Carine El-Sissy *INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.
Arnaud Serret-LarmandeECSTRRA Team, UMR-1153, Université Paris Cité, INSERM, AP-HP, Saint Louis Hospital, Paris, France.
Nikaïa SmithTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.
Morgane LebraudDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Jean-Loup AugyMedical intensive care unit, Hopital Delafontaine, 2 rue du Dr Delafontaine, Saint-Denis, 93200, France.
Catherine ContiUniversité Paris Cité, Paris, France.
Cécile GonninDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Benjamin PlanquetteService de Pneumologie Et Soins Intensifs, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Jean-Benoît ArletInternal Medicine Department, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Bertrand HermannMedical Intensive Care Unit, AP-HP. Centre Université Paris Cité, Georges Pompidou European Hospital, Paris, 75015, France.
Bruno CharbitInstitute of Ophthalmology, University College London (UCL), London, UK.
Jean PastreService de Pneumologie Et Soins Intensifs, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Floriane DevauxDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Cyrielle LadavièreDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Lydie LimDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Pauline OberDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Johanna CannovasDepartment of Geriatric Medicine, Hôpital Europeen Georges Pompidou, AP-HP, Paris, France.
Lucie BiardECSTRRA Team, UMR-1153, Université Paris Cité, INSERM, AP-HP, Saint Louis Hospital, Paris, France.
Marie-Christelle GulczynskiGérontologie 1, GHU AP-HP. Centre Université Paris Cité, Corentin Celton Hospital, Issy-Les-Moulineaux, 92130, France.
Noémie BlumenthalDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Hélène PéréVirology Laboratory, Hôpital Européen Georges-Pompidou, APHP.Centre - Université Paris Cité, Paris, France.
Camille KnospUniversité Paris Cité, INSERM, PARCC, Paris, France.
Alain GeyDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Nadine BenhamoudaDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Juliette MurrisHeKA, Inria Paris, Inserm, Université Paris Cité, Paris, France.
David VeyerVirology Laboratory, Hôpital Européen Georges-Pompidou, APHP.Centre - Université Paris Cité, Paris, France.
Eric TartourDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France.
Jean-Luc DiehlMedical Intensive Care Unit, AP-HP. Centre Université Paris Cité, Georges Pompidou European Hospital, Paris, 75015, France.
Darragh DuffyTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.
Elena PaillaudUniversité Paris Cité, Paris, France. elena.paillaud@aphp.fr.
Clémence GranierDepartment of Immunology, APHP, Hôpital Européen Georges Pompidou (HEGP), Paris, France. clemence.granier@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAgeing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize CD8

resultsOne hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated CD8

conclusionsOur results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care.

Indexed as

CD8-positive T-lymphocytesCOVID-19CXCL10GeriatricsGMCSFImmune-ageingImmunosenescenceInfectionsInflammagingSenescence-associated secretory phenotypeTSCM

Identifiers

PMID38715114
PMCPMC11075216

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.