Evidence map›Paper›PMID 38715647›Full record

ArticleAPL bioengineering2024

Model discovery approach enables noninvasive measurement of intra-tumoral fluid transport in dynamic MRI.

Ryan T Woodall, Cora C Esparza, Margarita Gutova, Maosen Wang, Jessica J Cunningham, Alexander B Brummer, Caleb A Stine, Christine C Brown, Jennifer M Munson, Russell C Rockne

Abstract read
In one paragraph

Article in APL bioengineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Weak-form inference for hybrid dynamical systems in ecology.Journal of the Royal Society, Interface · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ryan T WoodallDivision of Mathematical Oncology and Computational Systems Biology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, California 91010, USA.ORCID https://orcid.org/0000-0002-7978-8341
Cora C EsparzaFralin Biomedical Research Institute, Virginia Institute of Technology at Virginia Tech Carilion, Virginia Tech, 4 Riverside Circle, Roanoke, Virginia 24016, USA.
Margarita GutovaDepartment of Stem Cell Biology and Regenerative Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, California 91010, USA.
Maosen WangFralin Biomedical Research Institute, Virginia Institute of Technology at Virginia Tech Carilion, Virginia Tech, 4 Riverside Circle, Roanoke, Virginia 24016, USA.ORCID https://orcid.org/0000-0002-6302-0266
Jessica J CunninghamFralin Biomedical Research Institute, Virginia Institute of Technology at Virginia Tech Carilion, Virginia Tech, 4 Riverside Circle, Roanoke, Virginia 24016, USA.ORCID https://orcid.org/0000-0001-8704-8848
Alexander B BrummerDepartment of Physics and Astronomy, College of Charleston, 66 George Street, Charleston, South Carolina 29424, USA.ORCID https://orcid.org/0000-0002-8776-0939
Caleb A StineFralin Biomedical Research Institute, Virginia Institute of Technology at Virginia Tech Carilion, Virginia Tech, 4 Riverside Circle, Roanoke, Virginia 24016, USA.ORCID https://orcid.org/0000-0002-7540-9316
Christine C Brown
Jennifer M MunsonFralin Biomedical Research Institute, Virginia Institute of Technology at Virginia Tech Carilion, Virginia Tech, 4 Riverside Circle, Roanoke, Virginia 24016, USA.ORCID https://orcid.org/0000-0002-9477-1505
Russell C RockneDivision of Mathematical Oncology and Computational Systems Biology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, California 91010, USA.ORCID https://orcid.org/0000-0002-1557-159X

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Interstitial Fluid Flow Regulates Glioma Cell InvasionR37CA222563 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MUNSON, JENNIFER M · 2018 to 2024
$4.0M
Clinical Evaluation of Chlorotoxin-redirected Chimeric Antigen Receptor (CAR) T cells for Treatment of GlioblastomaR01CA254271 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BADIE, BEHNAM, BROWN, CHRISTINE · 2020 to 2024
$3.7M
The impact of interstitial fluid flow on CAR T cell trafficking, distribution, and efficacyR01NS115971 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI BROWN, CHRISTINE, MUNSON, JENNIFER M · 2021 to 2025
$3.3M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA254271NCI NIH HHS R37 CA222563NINDS NIH HHS R01 NS115971
6 · The paper itself

Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a routine method to noninvasively quantify perfusion dynamics in tissues. The standard practice for analyzing DCE-MRI data is to fit an ordinary differential equation to each voxel. Recent advances in data science provide an opportunity to move beyond existing methods to obtain more accurate measurements of fluid properties. Here, we developed a localized convolutional function regression that enables simultaneous measurement of interstitial fluid velocity, diffusion, and perfusion in 3D. We validated the method computationally and experimentally, demonstrating accurate measurement of fluid dynamics

Identifiers

PMID38715647
PMCPMC11075764

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.