Evidence map›Paper›PMID 38715796›Full record

ReviewFrontiers in endocrinology2024

Therapeutic advances in obesity management: an overview of the therapeutic interventions.

Moody Al Roomy, Kainat Hussain, Hawraa M Behbehani, Jenna Abu-Farha, Rayan Al-Harris, Aishwarya Mariam Ambi, Mohammed Altigani Abdalla, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Moody Al RoomyDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Kainat HussainDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Hawraa M BehbehaniDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Jenna Abu-FarhaDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Rayan Al-HarrisDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Aishwarya Mariam AmbiDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Mohammed Altigani AbdallaDepartment of Translational Research, Dasman Diabetes Institute, Kuwait City, Kuwait.
Fahd Al-MullaDepartment of Translational Research, Dasman Diabetes Institute, Kuwait City, Kuwait.
Mohamed Abu-FarhaDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.
Jehad AbubakerDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity has become a global epidemic in the modern world, significantly impacting the global healthcare economy. Lifestyle interventions remain the primary approach to managing obesity, with medical therapy considered a secondary option, often used in conjunction with lifestyle modifications. In recent years, there has been a proliferation of newer therapeutic agents, revolutionizing the treatment landscape for obesity. Notably, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide, liraglutide, and the recently approved dual GLP-1/GIP RAs agonist tirzepatide, have emerged as effective medications for managing obesity, resulting in significant weight loss. These agents not only promote weight reduction but also improve metabolic parameters, including lipid profiles, glucose levels, and central adiposity. On the other hand, bariatric surgery has demonstrated superior efficacy in achieving weight reduction and addressing overall metabolic imbalances. However, with ongoing technological advancements, there is an ongoing debate regarding whether personalized medicine, targeting specific components, will shape the future of developing novel therapeutic agents for obesity management.

Indexed as

Anti-Obesity AgentsBariatric SurgeryObesityObesity ManagementGlucagon-Like Peptide-1 Receptor AgonistsHumansWeight LossAnti-Obesity AgentsGlucagon-Like Peptide-1 Receptor AgonistsbariatricGLP-1 RAsobesitytirzepatideweight loss

Identifiers

PMID38715796
PMCPMC11074390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.