Evidence map›Paper›PMID 38716651›Full record

ArticleCancer medicine2024

It provides families with other avenues for treatment when there are no other options Surgeons' perspectives of being part of a precision medicine trial for poor prognosis paediatric cancer patients: A short report.

Rebecca Daly, Kate Hetherington, Bethany R Wadling, Chris Jacobs, Jonathan Karpelowsky, Claire E Wakefield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebecca DalyDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW, Sydney, New South Wales, Australia.ORCID 0000-0003-1096-0526
Kate HetheringtonDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW, Sydney, New South Wales, Australia.ORCID 0000-0002-5457-5462
Bethany R WadlingDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW, Sydney, New South Wales, Australia.
Chris JacobsGraduate School of Health, University of Technology Sydney, Sydney, New South Wales, Australia.
Jonathan KarpelowskyDepartment of Paediatric Surgery, Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Claire E WakefieldDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW, Sydney, New South Wales, Australia.

Funding

Cancer Institute Translational Program Grant 2021/TPG2112Kids with Cancer FoundationLuminesce Alliance - Innovation for Children's HealthNHMRC of Australia APP2008300Zero Childhood Cancer National Personalised Medicine Program
6 · The paper itself

Abstract

objectivePrecision medicine is transforming cancer treatment, yet the perspectives of surgeons who often play a critical role in the delivery of precision medicine remain understudied.

methodsWe conducted semi-structured interviews with 13 surgeons involved in a precision medicine trial for children with poor prognosis cancer. We explored knowledge of genetics, confidence with somatic and germline results, ratings of benefit to stakeholders and willingness to undertake surgical procedures.

resultsSurgeons generally had positive attitudes towards precision medicine but expressed concerns about families' unrealistic expectations, mixed opinions on the benefits and the use of research-only biopsies. Most surgeons rated their genetics knowledge as 'good' (69%) and felt 'very confident' in identifying genetic specialists (66%), but 'not confident' (66.6%) in making treatment recommendations. Surgeons' willingness to undertake a procedure was influenced by potential patient benefit.

conclusionsOur findings support the need for more workforce and training support for surgeons to fully engage with precision medicine.

Indexed as

Attitude of Health PersonnelNeoplasmsPrecision MedicineSurgeonsAdultChildFamilyFemaleHealth Knowledge, Attitudes, PracticeHumansMalePrognosiscancerprecision medicinesurgeon

Identifiers

PMID38716651
PMCPMC11077424

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.