Evidence map›Paper›PMID 38717697›Full record

Trial reportClinical oral investigations2024

Evaluation of the effects of pregabalin and dexamethasone coadministration on preemptive multimodal analgesia and anxiety in third molar surgeries: a triple-blind randomized clinical trial.

Jiordanne Araújo Diniz, Ana Cláudia Amorim Gomes Dourado, Davi da Silva Barbirato, Maysa Swellen Valentim de Oliveira, Vitória Layla Bezerra de Oliveira de Lira, Sérgio Murilo Cordeiro de Melo Filho, Karoline Gomes da Silveira, José Rodrigues Laureano Filho

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiordanne Araújo DinizDivision of Oral and Maxillofacial Surgery, Dental School, University of Pernambuco, Arnóbio Marques St., 310, Recife, 50100-130, PE, Brazil. jiordanne.diniz@upe.br.
Ana Cláudia Amorim Gomes DouradoProfessor of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, PE, Brazil.
Davi da Silva BarbiratoPostdoctoral Fellowship in Oral and Maxillofacial Surgery, University of Pernambuco, Recife, PE, Brazil.
Maysa Swellen Valentim de OliveiraGraduating in Dentistry, University of Pernambuco, Recife, PE, Brazil.
Vitória Layla Bezerra de Oliveira de LiraGraduating in Dentistry, University of Pernambuco, Recife, PE, Brazil.
Sérgio Murilo Cordeiro de Melo FilhoPostgraduate resident, Oral and Maxillofacial Surgery, University of Pernambuco, Recife, PE, Brazil.
Karoline Gomes da SilveiraPostgraduate Ph.D. in Oral and Maxillofacial Surgery, University of Pernambuco, Recife, PE, Brazil.
José Rodrigues Laureano FilhoProfessor of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, PE, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of pregabalin and dexamethasone coadministration in preemptive analgesia and anxiety control in lower third molar surgery. MATERIALS AND

methodsA triple-blind, split-mouth clinical trial conducted with patients divided into two groups: control group, receiving placebo and dexamethasone, and test group, receiving pregabalin and dexamethasone preoperatively. The evaluated variables were pain, measured by the Visual Analog Scale (VAS), anxiety assessed through the State-Trait Anxiety Inventory (STAI) questionnaires, hemodynamic parameters [Blood Pressure (BP), Heart Rate (HR), Oxygen Saturation (SpO

resultsA total of 31 patients were included. The test group exhibited a significant reduction in pain at 2,4,6,8,12,16,24, and 48 h after surgery and in the consumption of rescue analgesics. Anxiety, evaluated by STAI and VAS, showed a significant decrease in the test group (p < 0.001). Additionally, there was a significant decrease in BP at most of the assessed time points (p < 0.05) and a significant reduction in HR at two different time intervals (p = 0.003 and p = 0.009), indicating a positive effect in the test group. There was no significant difference in SpO

conclusionsPregabalin coadministered with dexamethasone demonstrated significant efficacy in controlling postoperative pain and anxiety, as well as a sedative effect. CLINICAL RELEVANCE: The coadministration of pregabalin with dexamethasone may presents potential advantages in both pain modulation and psychological well-being of individuals undergoing third molar surgeries.

trial registrationBrazilian Clinical Trials Registry (REBEC), No. RBR-378h6t6.

Indexed as

AnalgesicsDexamethasoneDrug Therapy, CombinationMolar, ThirdPain MeasurementPostoperative PainPregabalinTooth ExtractionAdultDental AnxietyFemaleHumansMalePain ManagementSurveys and QuestionnairesTreatment OutcomeAnalgesicsDexamethasonePregabalinAnxietyConscious sedationDexamethasonePainPregabalinThird molar

Identifiers

PMID38717697

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.